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EC number: 928-726-1 | CAS number: 1179913-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- The log Kow values for Fluoranthene and DDT were taken from the EU guideline A.8 instead of OECD 117, as the registration of the compound is for REACH. This deviation is stated as uncritical, as the difference is marginal only.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch no.: #210162718
Composition: Reaction products of linseed-oil fatty acids, 4,4'-methylendiphenyldiglycidylether with neodecanoic fatty acid, oxiranylmethylester
Purity: 100 % as per definition of UVCB - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.2
- Temp.:
- 25 °C
- pH:
- ca. 7
- Details on results:
- The test substance peaks showed retention times between 1.425 min and 37.647 min, with 99.8% of the peak areas eluting after the standard with highest logPow, DDT (the reference substance - log Pow = 6.20). The determination was precise with very low standard deviations of < 0.20 min. The calculation of the log Pow of the test substance peaks was not possible, because the peaks eluted outside the isocratic part of the HPLC program. Extrapolation was therefore not possible. Because the retention times of the test substance peaks were higher than the retention time of DDT (10.506 min), the log Pow of the test substance was stated as > 6.2 (log Pow of DDT).
- Conclusions:
- Under the study conditions, the partition coefficient (log Kow) of the test substance was determined to be > 6.2 (HPLC method).
- Executive summary:
A study was conducted to determine the partition coefficient of the test substance according to OECD Guideline 117 and EU Method A.8 (HPLC method). One vial was filled with the reference substance (DDT) mix and one vial with the test substance solution. The vials were analysed using the HPLC. Three injections each were measured from the reference substance mix, the test substance solution and again from the reference substance mix. The data was saved, the retention times of the nine peaks of the reference substance mix and the retention times of the peaks of the test substance were used for further calculations. The test substance peaks showed retention times between 1.425 min and 37.647 min, with 99.8 % of the peak areas eluting after the standard with highest logKow, DDT (the reference substance - log Kow = 6.20). The determination was precise with very low standard deviations of < 0.20min. The calculation of the log Kow of the test substance peaks was not possible, because the peaks eluted outside the isocratic part of the HPLC program. Extrapolation was therefore not possible. Because the retention times of the test substance peaks were higher than the retention time of DDT (10.506 min), the log Kow of the test substance was stated as > 6.2 (i.e. log Kow of DDT), under the study conditions (2016).
Reference
Description of key information
The partition coefficient was determined according to OECD Guideline 117 and EU Method A.8 (HPLC method) (Johannes, 2016) as well as using KOWWIN v.1.68 of EPISuite v.4.1 (US EPA, 2016).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 10
- at the temperature of:
- 25 °C
Additional information
The log Kow of the test substance could not be determined from the experiment, as its peak eluted outside the isocratic part of the HPLC program; hence log Kow was concluded to be higher than the reference substance (i.e., >6.2). The estimated log Kow values for the major constituents using KOWWIN v.1.68 of EPISuite v.4.1 were found to be ≥10 (refer to Annex 3 for further details).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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