Registration Dossier
Registration Dossier
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EC number: 601-101-8 | CAS number: 111497-86-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- Test performed at pH 7.
- GLP compliance:
- no
- Radiolabelling:
- no
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- After 1 hour, the formation of N,N diethyl amino propionic acid (MW: 145 g/mol; C7H15O2N) reached its maximum concentration (57% w of DEA-AA correspond to ca. 90% hydrolysis).
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 104 d
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 11 h
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 1 h
- Conclusions:
- Under the test conditions, the test substance was subject to hydrolysis at pH 7, 24.1°C (into DEA-AA and TPG).
- Executive summary:
A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods.
In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9.
The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG).
Reference
In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Also, degradation half-life decreased with increasing temperature at pH7.
Description of key information
A study was performed to determine the hydrolysis potential of the test substance at pH 4, 7 and 9 using GC and LC-MS analytical methods. In a preliminary study at 50°C, the test substance degraded rapidly at all pH values. Further, degradation half-life decreased with increasing temperature at pH 7. At 25°C, the half-life was 104 d at pH 4, 11 h at pH 7 and < 1 h at pH 9. This corresponds to a half-life of 1.3 d at 12°C (pH 7). The degradation products were diethyl amino propionic acid (DEA-AA) and tripropylene glycol (TPG) (Parent, 2007).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 11 h
- at the temperature of:
- 25 °C
Additional information
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