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EC number: 310-202-3 | CAS number: 37206-42-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2004 to July 2004
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Read across data is presented from the structurally related substance, 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1. This substance bears a close structural similarity to 1,1"-isopropylidenebis(ethylferrocene), CAS Number 37206 -42 -1, EC Number 310 -202 -3, the distinction being that the alkyl bridging functionality between the two ferrocene moieties is an octyl derivative as opposed to an isopropyl derivative and that two cyclopentadienyl moieties in the target substance bear ethyl substituents.
- Vehicle:
- yes
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: 100 mg/L acetone.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The Daphnia were bred in the laboratories of LAB International, Hungary under similar temperature and light conditions as in the test, and in reconstituted water of similar quality regarding pH, components of the main ions and total hardness of the test water used in the test. The age of the Daphnia at the start of the test were 6.7 - 21.7 hours old.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- The hardness (CaCO3) of the water was : 168.4 mg/L.
- Test temperature:
- 18 - 22 degrees C
- pH:
- 7.93 - 7.97
- Dissolved oxygen:
- > 92%
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.36 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.36 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- In an OECD 202 study, 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1 has an 48 hour EC50 of > 0.36mg/L (measured) to Daphnia Magna. The NOEC was 0.36mg/L. The nominal value added to the water of 0.5mg/L is 10x the water solubility of the substance.
- Executive summary:
The short-term toxicity to aquatic invertebrates of 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1was investigated in accordance with the standardised guideline OECD 202.
An OECD 202 study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results was performed on 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1.
The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
This substance is considered to be sufficiently close in structural integrity to 1,1"-isopropylidenebis(ethylferrocene), CAS Number 37206 -42 -1, EC Number 310 -202 -3 so as to justify valid read across.
Under the conditions of the study the EC50 was determined to be > 0.36 mg/L and the NOEC was 0.36 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Study duration was only 24 hours
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Read across data is presented from the structurally related substance, iron(2+) dicyclopenta-2,4-dienide (ferrocene), CAS Number 102-54-5, EC Number 203-039-3. This substance bears a close structural similarity to 1,1"-isopropylidenebis(ethylferrocene), CAS Number 37206 -42 -1, EC Number 310 -202 -3. Therefore, it is considered that read-across is valid.
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 24 h
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 2.5 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Technical product, undiluted
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 4 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Technical Product, diluted in Acetone
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.5 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Sublimed and uncrystallised product, diluted in acetone
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.2 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Technical product, dilued in Acetone
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 0.5 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Remarks on result:
- other: Sublimed and uncrystallised product, diluted in Acetone
- Validity criteria fulfilled:
- yes
- Conclusions:
- 3 forms of ferrocene were tested in a study performed that was similar to OECD Guideline 202. Between the 3 different forms, EC50 values showed no hugely significant differences. Technical grade product diluted in Acetone gave EC50 24hr = 4 mg/l, sublimed and uncrystallised products both diluted in acetone gave EC50 24hr = 1.5 mg/l. They show however, that in acute tests daphnia magna are somewhat more sensitive to ferrocene than fish. For a CSA value as this study was only performed for 24 hours, the EC50 values have been decreased by 50% to allow for 48 hour exposure. Therefore technical grade product diluted in Acetone has an EC50 48hr = 2 mg/l with sublimed and uncrystallised products both diluted in acetone, having EC50 48 hr = 0.75 mg/l. Value used in CSA is EC50 (48hr) = 1.17 mg/l.
- Executive summary:
The short-term toxicity to aquatic invertebrates of iron(2+) dicyclopenta-2,4-dienide (ferrocene), CAS Number 102-54-5, EC Number 203-039-3 was investigated in a study which was equivalent or similar to guideline OECD 202.
The study was assigned a reliability score of 2 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
This substance is considered to be sufficiently close in structural integrity to 1,1"-isopropylidenebis(ethylferrocene), CAS Number 37206 -42 -1, EC Number 310 -202 -3 so as to justify valid read across.
3 forms of ferrocene were tested in a study performed that was similar to OECD Guideline 202. Between the 3 different forms, EC50 values showed no hugely significant differences. Technical grade product diluted in Acetone gave EC50 24hr = 4 mg/l, sublimed and uncrystallised products both diluted in acetone gave EC50 24hr = 1.5 mg/l. They show however, that in acute tests daphnia magna are somewhat more sensitive to ferrocene than fish. For a CSA value as this study was only performed for 24 hours, the EC50 values have been decreased by 50% to allow for 48 hour exposure. Therefore technical grade product diluted in Acetone has an EC50 48hr = 2 mg/l with sublimed and uncrystallised products both diluted in acetone, having EC50 48 hr = 0.75 mg/l. Value used in CSA is EC50 (48hr) = 1.17 mg/l.
Referenceopen allclose all
Description of key information
Two studies are presented on structurally related substances as valid read across candidates: 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1 (OECD 202) and Iron(2+) dicyclopenta-2,4-dienide (Ferrocene), CAS Number 102-54-5, EC Number 203-039-3 (equivalent or similar to OECD 202).
Both substances are considered to be sufficiently close in structural integrity to 1,1"-isopropylidenebis(ethylferrocene), CAS Number 37206 -42 -1, EC Number 310 -202 -3 so as to justify valid read-across.
In an OECD 202 study, 1,1'-Bis(ferrocenyl)octane, CAS Number 501410-94-2, EC Number 479-710-1 has an 48 hour EC50 of > 0.36mg/L (measured) to Daphnia Magna. The NOEC was 0.36mg/L. The nominal value added to the water of 0.5mg/L is 10x the water solubility of the substance.
In the case of iron (2 +) dicyclopenta-2,4 -dienide (ferrocene), CAS Number 102 -54 -5, EC Number 203 -039 -3, three forms of the substance were tested in a study performed that was similar to OECD Guideline 202. Between the 3 different forms, EC50 values showed no hugely significant differences. Technical grade product diluted in Acetone gave EC50 24hr = 4 mg/l, sublimed and uncrystallised products both diluted in acetone gave EC50 24hr = 1.5 mg/l. They show however, that in acute tests daphnia magna are somewhat more sensitive to ferrocene than fish. For a CSA value as this study was only performed for 24 hours, the EC50 values have been decreased by 50% to allow for 48 hour exposure. Therefore technical grade product diluted in Acetone has an EC50 48hr = 2 mg/l with sublimed and uncrystallised products both diluted in acetone, having EC50 48 hr = 0.75 mg/l. Value used in CSA is EC50 (48hr) = 1.17 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.36 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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