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EC number: 275-809-7 | CAS number: 71662-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information are included in the Read-Across Justification Document. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 155 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Remarks on result:
- other: Duration equivalent to 120d post hatch
- Key result
- Duration:
- 155 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Duration equivalent to 120d post hatch
- Key result
- Duration:
- 155 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Duration equivalent to 120d post hatch
- Details on results:
- - Mortality/survival at embryo and larval stages: 100% survival at hatching
- Overall mortality/survival: 95-98% in all groups including controls see table below
- Days to hatch and numbers hatched: 35-36 20/replicate & 2 replicates /group
- Data for length and weight of surviving fish: see table below
- Type of and number with morphological abnormalities: 0 in all groups
- Type of and number with behavioural abnormalities: 0 in all groups
- Other biological observations: No
- Effect concentrations exceeding solubility of substance in test medium: N/A
- Incidents in the course of the test which might have influenced the results: day 148 injector delivery tubes removed for 5.5h resulted in a temporary reduction in DUP concentrations.
During growth phase dissolved oxygen concentrations d42-155, within & across concentrations exhibited a downward trend; from d112-119 there were occasional dips below 60% saturation (min 6.2 mg/l). From day 119 an O2 injection system was used to try and improve the concentrations which remained low despite further modifications involving discontinuation of gaseous oxygen. - Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- Embryo hatchability &survival: Fisher's Exact Test & Frequency analysis
Growth & wet body weight: t test for differences between controls; ANOVA & Dunnett's test (1 tailed) for differences between vehicle control and DUP treated groups - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this test the NOEL mean measured concentration for DUP was 0.30 mg/l, the maximum water solubility in these conditions.
- Executive summary:
Long-term toxicity to fish with the structurally related substance Diundecyl phthalate has been determined in a fish early life stage test with rainbow trout. Under the conditions of the test the NOEC, based on the mean measured concentration, was 0.30 mg/l, the highest concentration investigated and regarded as the maximum water solubility under the test conditions.
Reference
Swim up began on day 45, 10 days post hatch and was completed by day 50, 15 days post hatch. It began & proceeded at the same rate in all groups.
There were no DUP related effects on appearance, behaviour or feeding. Length and wet weight were also not affected by exposure to DUP at any of the concentrations tested.
Embryo hatchability and survival of rainbow trout exposed to diundecyl phthalate
Parameters (%) |
0 (Control) |
0 (Vehicle control) |
Mean measured concentrations of DUP (mg/l) |
||||
0.026 |
0.039 |
0.075 |
0.15 |
0.30 |
|||
Embryo hatch |
100 |
100 |
100 |
100 |
100 |
100 |
100 |
60 d post hatch survival |
953 |
98 |
95 |
98 |
98 |
100 |
95 |
90 d post hatch survival |
95 |
972 |
95 |
97 |
98 |
100 |
95 |
120 d post hatch survival |
95 |
97 |
95 |
97 |
98 |
100 |
95 |
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1 = no. in each replicate n = 20; 2 n = 19, 1 escaped from 1 replicate & not included in value for mortality; 3 = n= 18, 2 escaped from 1 replicate & not included in value for mortality; 4 = n= 17, 3 escaped from 1 replicate & not included in value for mortality
Post hatch mean standard length & blotted wet weight of rainbow trout exposed to diundecyl phthalate
Parameters (%) |
0 (Control) |
0 (Vehicle control) |
Mean measured concentrations of DUP (mg/l) |
||||
0.026 |
0.039 |
0.075 |
0.15 |
0.30 |
|||
Standard length (mm) |
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60 d post hatch |
53.807 (3.529) |
54.499 (2.532) |
55.997 (2.896) |
55.149 (3.315) |
55.630 (2.762) |
56.631 (2.894) |
57.884 (2.935) |
90 d post hatch |
79.003 (5.828) |
79.680 (5.368) |
81.575 (6.062) |
80.236 (6.437) |
80.729 (4.176) |
81.945 (5.883) |
84.404 (5.815) |
120 d post hatch |
108.34 (9.123) |
106.46 (8.035) |
110.89 (10.135) |
108.27 (9.879) |
107.93 (6.655) |
108.91 (9.127) |
112.35 (8.965) |
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Blotted wet weight (g) |
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120 d post hatch |
20.676 (5.817) |
19.957 (5.118) |
22.735 (6.496) |
21.230 (6.099) |
20.107 (4.310) |
20.776 (5.986) |
23.433 (6.491) |
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Description of key information
The NOEC in fish for the structural related substance 1,2-Benzenedicarboxylic acid, diundecyl ester is reported as 0.3 mg/l and hence well above the limit of water solubility. Therefore it can be concluded that no toxicity occurred up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Long-term toxicity to fish has been determined with the structurally related substance 1,2-Benzenedicarboxylic acid, diundecyl ester in a fish early life stage test with rainbow trout. Under the conditions of the test the NOEC (155d), based on the mean measured concentration, was 0.30 mg/l, the highest concentration investigated and regarded as the maximum water solubility under the test conditions.
Further supporting these findings, no effects or either effects far above the limit of water solubility were found in Early life stage tests with the lower-molecular-weight phthalate esters, 1,2-Benzenedicarboxylic acid, dihexyl ester (Rainbow trout, 143 d) and 1,2-Benzenedicarboxylic acid, dioctyl ester (Fathead minnow, 28 d), 0.22 mg/L (NOEC) and 3.2 mg/L (NOEC) respectively.
All values are well above the level of water solubility (see Staples et al., 1997).
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