Registration Dossier
Registration Dossier
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EC number: 272-056-6 | CAS number: 68672-66-2
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water
Reference
Description of key information
Pre-test solubility work was performed to check the feasibility of hydrolysis testing, where it
was discovered that the test item is extremely insoluble in aqueous solutions, i.e., the
solubility was determined to be less than 0.01 mg/L in pH 4, 7 and 9 buffer solutions.
Furthermore, EpiSuite v4.11 predicts the water solubility as 9.87 x 10e-6 mg/L (using
WSKOW v1.42) and 5.047 x 10e-4 mg/L (using WaterNT v1.01).
Therefore, as testing to Method 111 of the OECD Guidelines for Testing of Chemicals,
13 April 2004 has to be performed at no greater than 50 % saturation level and detect
accurately from the initial test concentration down to less than 10% remaining, it was
considered that hydrolysis testing on this test item was not feasible.
Key value for chemical safety assessment
Additional information
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