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EC number: 268-776-5 | CAS number: 68140-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data are provided for the submission substance. Endpoints are addressed by read across to available data for the major components of the submission substance (AAI_DETA and Rosin). Based on read across to data obtained with AAI_DETA, DTO_DETA is considered to be corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- It is considered appropriate to address the data requirements for DTO_DETA by read-across to the available studies on the main components of DTO_DETA: AAI_DETA and Rosin.
DTO_DETA contains comparatively lower levels of imidazolines and higher levels of resin acids than AAI_DETA and therefore consideration of data for resin acids is also considered necessary. The main resin acid in DTO_DETA is abietic acid, but abietic acid derivatives and other acids, such as pimaric acid, are also found in notable quantities, and the resin acids collectively are known as ‘rosin’. DTO_DETA contains up to 25% unreacted rosin, and taking into account the compositional information available for the rosin in DTO_DETA and Rosin (CAS# 8050-09-07, EC# 232-475-7), the latter was considered appropriate for read-across to DTO_DETA.
In vitro and in vivo studies conducted on Rosins indicate that these substances are not skin irritants. However AAI_DETA was found to be corrosive to rabbit skin in an in vivo guideline study (CIT, 2008). As the AAI_DETA dataset is clearly worst case with respect to skin irritation/corrosion, and therefore read across to AAI_DETA is considered appropriate for the target substance, DTO_DETA. - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4-hour exposure
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within:
- Remarks:
- 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4-hour exposure
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Severe burn observed on Day 2; animal sacrificed for ethical reasons
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Severe burn observed on Day 2; animal sacrificed for ethical reasons
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Based on the results of the read across study, DTO_DETA is considered to be corrosive to rabbit skin following a 4-hour application. Classification according to CLP is required (Cat 1C, corrosive).
- Executive summary:
A guideline (OECD 404) in vivo skin irritation study (CIT, 2008) is available for the read across (source) substance, AAI_DETA. Read across from AAI_DETA to the target, DTO_DETA, is considered appropriate because AAI_DETA is a major component of DTO_DETA. AAI_DETA was found to be corrosive to rabbit skin following a four hour exposure period, and classification in Category 1C for skin corrosion was assigned according to CLP.
Reference
First animal: 3-min: moderate to severe erythema up to day 8 and very slight erythema still at day 15. Slight oedema was visible from day 2 until day 8, and was completely resolved by day 10. 1-hour: moderate to severe erythema up to day 11 and very slight erythema still at day 15. Slight oedema was visible from day 2 until day 13, and was completely resolved on day 14. 4-hours: moderate to severe erythema up to day 13 and very slight erythema still at day 15. Slight oedema was visible from day 2 until day 13, and was completely resolved on day 14. With all exposure durations, a brownish area at the application site was noted from day 2 until day 10. Crusts and dryness of the skin were noted between day 5 and day 15 (end of the observation period). Second animal: 4-hours: a moderate then a severe erythema (grade 3 then 4) was noted on days 1 and 2, respectively. A severe edema (grade 4) was noted on days 1 and 2. A red-brown area was noted on day 2. Cutaneous reactions observed in the second animal were similar to a severe burn, and animal was sacrificed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data are available for the target substance, DTO_DETA. Read across to skin irritation studies conducted on the major components of DTO_DETA is considered appropriate and sufficient for classification. No information is available for respiratory irritation.
Justification for classification or non-classification
Based on read across to data available for AAI_DETA (a major component of DTO_DETA), DTO_DETA should be classified as Skin Corrosive Category 1C 'Causes severe skin burns and eye damage' according to CLP. No classification is proposed for respiratory irritation, in the absence of relevant data.
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