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EC number: 266-018-8 | CAS number: 65996-84-1 The reaction product obtained by neutralizing coal tar base extract oil with an alkaline solution, such as aqueous sodium hydroxide, to obtain the free bases. Composed primarily of such organic bases as acridine, phenanthridine, pyridine, quinoline and their alkyl derivatives.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 30 Jul. – 04 Oct. 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- open test system
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Coal tar bases
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Substance type: organic
- Physical state: liquid
- Stability under test conditions: WAF (water accommodated fraction) limited
- Storage condition of test material: room temperature, exclusion of light
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples for TOC-analysis were taken at 0 h and 48 h
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test item Coal tar bases is a fluid, fully miscible in water. Test solutions were prepared in a dilution series of a stock solution
of 100 mg/L test item in Daphnia-medium. The stock solution and each degree of dilution were emulsified at 13500 rpm for 5 minutes
using a mixing device (Ultra-Turrax, Janke & Kunkel).
- Test concentrations: control, 1 mg/L, 10 and 100 mg/L (range finding)
control, 1 mg/L, 2.5 mg/L, 5 mg/L, 25 mg/L, and 50 mg/L
- Controls: without test material (blank; Daphnia medium)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): none
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia
- Strain: --
- Source: origin German Environmental Ministry
- Age at study initiation (mean and range, SD): =< 24 h
- Method of breeding: The animals are cultivated in a climate-controlled room (light/dark = 14 h/10 h; illumination: Gro-Lux fluorescent tubes).
- Feeding during test
- Food type: The animals are fed with algae (Desmodesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- see data under "salinity"
- Test temperature:
- 20.1 – 20.4 °C (20 °C ± 2 °C)
- pH:
- 8.0 - 8.2 at 0, 24 and 48 h
- Dissolved oxygen:
- 7.8 - 8.2 mg/L at 0, 24 and 48 h
- Salinity:
- The total of Ca- and Mg-ions was 2.5 mmol/L, the ratio of Ca/Mg was 4:1, the ratio of Na/K was 10:1. The total alkalinity of the solution was 0.8 mmol/L, the pH-value was 7.8 ± 0.2.
- Nominal and measured concentrations:
- Main test series:
Time [h] Control 1 mg/L 10 mg/L 50 mg/L (nominal TS concentration)
==========================================================
0 0.2 0.7 7.6 37.4 mg/L (TOC of WAF)
48 0.41 1.0 7.7 36.0 mg/L (TOC of WAF)
==================================================== - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: glass beaker, 50 mL, test volume: 20 mL
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): not applicable
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Deionised water, was aerated until saturation.
- Total organic carbon: 0.2-0.4 mg/L
- Alkalinity: 0.8 mmol/L
- Ca/Mg ratio: 4:1
- Conductivity: no data
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
- Light intensity: no data, Gro-Lux fluorescent tubes
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2 - 2.5
- Range finding study
- Test concentrations: 1, 10 and 100 mg/L (nominal)
- Results used to determine the conditions for the definitive study:
immobilisation 70 % at 1 mg/L
immobilisation 100 % at 10 and 100 mg/L
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Remarks:
- effective loading
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Remarks:
- No-observed effect loading rate
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOELR
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks:
- 4/20 (20 %) immobile
- Details on results:
- - Other biological observations: number of moulds incipient reduction from 5 mg/L
- Mortality of control: 0/20
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: none
- Effect concentrations exceeding solubility of substance in test medium: none - Reported statistics and error estimates:
- not applicable
Any other information on results incl. tables
Table 1: Immobilisation rate in dependence of time and concentration, number of carapace moults, and
number of living animals trapped at the surface [number per total animals, %] (Report Tab. 6)
Control |
1 mg/L |
2.5 mg/L |
5 mg/L |
10 mg/L |
25 mg/L |
50 mg/L |
||||||||
Number |
[%] |
Number |
[%] |
Number |
[%] |
Number |
[%] |
Number |
[%] |
Number |
[%] |
Number |
[%] |
|
Immobilisation 24 h |
0/20 |
0 |
0/20 |
0 |
8/20 |
40 |
11/20 |
55 |
6/20 |
30 |
1020 |
50 |
11/20 |
55 |
Immobilisation 48 h |
0/20 |
0 |
4/20 |
20 |
14/20 |
70 |
18/20 |
90 |
18/20 |
90 |
18/20 |
90 |
15/20 |
75 |
Moults 48 h |
19/20 |
95 |
18/20 |
90 |
18/20 |
90 |
15/20 |
75 |
6/20 |
30 |
5/20 |
25 |
2/20 |
10 |
Living animals at |
0/20 |
0 |
0/20 |
0 |
0/20 |
0 |
0/20 |
0 |
0/20 |
0 |
0/20 |
0 |
0/20 |
0 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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