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EC number: 263-134-0 | CAS number: 61790-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Principles of method if other than guideline:
- The test substance is exposed to a known and constant nitrogen flow in the oven of a Thermo Gravimetric Analyzer (TGA) at defined elevated isothermal temperatures. The evaporation rate (vT) at each test temperature is determined by monitoring the weight loss over appropriate periods of time. The relationship between the logarithm of the evaporation rate (log vT) and the reciprocal of the temperature (1/T) is linear. By linear extrapolation of this relationship to 20°C the evaporation rate at this temperature (vT,20) is normally calculated by linear regression (least squares method). This evaporation rate is used to calculate the vapor pressure at 20°C (pT,20) by using the linear relationship between log vT,20 and log pT,20. This relationship is determined by calibration of the test equipment with five reference substances with known vapor pressures at 20°C. This method is suitable for substances with (very) low vapor pressures and with purity as close as possible to 100% to avoid the misinterpretation of measured weight losses from more volatile impurities. The vapor pressure of a substance is expressed in Pascal (Pa).
- GLP compliance:
- no
- Other quality assurance:
- other: ISO 9001
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0 Pa
- Conclusions:
- Under the study conditions, the vapour pressure of the test substance at 20°C was determined to be 3.0E-9 Pa.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance, TMAC S (88.3% active), using the isothermal thermogravimetry effusion method, according to EU Method A.4, in compliance with ISO-9001. Under the study conditions, the vapour pressure of the test substance was determined to be 3.0E-9 Pa at 20°C (Boerdijk, 2018).
Reference
Calibration
The calibration was carried out less than a month before this study. For each reference substance the evaporation rate at 20°C, determined in this calibration, and the known vapor pressure are mentioned in the table below. The calibration resulted in the following values:
- constant C : 1.208
- constant D : 3.996
- r2 : 0.9976
- n : 5
Reference substance |
P20 [Pa] |
log p20 |
v20 [g.cm-2.h-1] |
log v20 |
Naphthalene |
7.20 x 10 |
+ 0.857 |
2.45 x 10-3 |
- 2.610 |
n-Octadecane |
1.46 x 10-2 |
- 1.835 |
1.04 x 10-5 |
- 4.985 |
Hexachlorobenzene |
1.47 x 10-3 |
- 2.833 |
2.28 x 10-6 |
- 5.642 |
Chrysene |
8.40 x 10-7 |
- 6.076 |
9.06 x 10-9 |
- 8.043 |
Benzo(g,h,i)perylene |
1.33 x 10-8 |
- 7.876 |
9.93 x 10-11 |
-10.003 |
Check of nitrogen flow rate
The flow rate was within the range of 52 mL/min.
Vapor pressure of test substance
The evaporation rate of the test substance was measured at 152°C till 209°C:
Temperature [°C] |
v20 [g.cm-2.h-1] |
log v20 |
151.9 |
2.52 x 10-4 |
-3.600 |
161.3 |
4.43 x 10-4 |
-3.354 |
170.8 |
8.78 x 10-4 |
-3.057 |
180.4 |
1.73 x 10-3 |
-2.761 |
190.0 |
3.41 x 10-3 |
-2.467 |
199.7 |
7.23 x 10-3 |
-2.141 |
209.4 |
1.46 x 10-2 |
-1.836 |
Log V(T) = -6331.4* (1/T) + 11.2366
At 20°C,
Log V(20) = -6331.4/293.15 + 11.2366 = -10.361
V20 = 10-10.361 = 4.355 x 10-11 g.cm-2.h-1.
The evaporation rate at 20°C can be calculated from the measured rates between 152°C and 209°C by linear extrapolation of log vT versus 1/T according to equation (2).
This results in: v20 = 4.355 x 10-11 g.cm-2.h-1.
Log p(20) = 1.2077 * log V20 + 3.9963 = 1.2077 * (-10.361)+ 3.9963 = -8.517
Vapour pressure of test substance at 20°C = p(20) = 10-8.517 = 3.0*10-9 Pa
The vapor pressure of the test substance at 20°C can be calculated by using equation (3).
This results in: p20 = 3.0 x 10-9 Pa.
Results
The vapor pressure of test substance at 20°C can be calculated by using equation (3).
Vapour pressure of test substance at 20°C = p(20) = 10-8.517 = 3.0E-9 Pa
Description of key information
The vapour pressure of the test substance was determined using the isothermal thermogravimetric effusion method, according to EU Method A.4 (Boerdijk, 2018).
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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