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Diss Factsheets
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EC number: 252-552-9 | CAS number: 35415-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- < 108 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A, limit test
- Remarks:
- corrected for the molecular weight of the target substance
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 108 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A, limit test
- Remarks:
- corrected for the molecular weight of the target substance
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 108 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: N/A, limit test
- Remarks:
- corrected for the molecular weight of the target substance
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h-LC50 (Oryzias latipes, mortality) was >108 mg/L (corrected for the molecular weight of the target substance).
- Executive summary:
The study used as source investigated acute toxicity to fish (Oryzias latipes) during 96 hours of exposure according to OECD 203 and in compliance with GLP. The 96h-LC50 (Oryzias latipes, mortality) was determined to be >108 mg/L (corrected for the molecular weight of the target substance). The validity criteria of the test guideline were fulfilled and results of the source compound were considered applicable to the target compound. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross-reference “assessment report”.
Reference
Description of key information
No acute toxicity data on fish for the submission substance is available. However adequate and reliable data for structural analogues is available (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13). The derived 96h-LC50 (Oryzias latipes, mortality) was >108 mg/L (corrected for the molecular weight of the target substance).
Key value for chemical safety assessment
Additional information
No acute aquatic toxicity data for the submission substance is available. However adequate and reliable data for structural analogues (i.e. C8TM and C8C10TM, for read-across justification please see read-across report in section 13) are reported below.
In a reliable acute toxicity study on fish (according to OECD 203 and in compliance with GLP, MoE Japan, 2001, RL2) no mortality was observed in a limit test at 100 mg/L test substance (analogue substance: trioctyl benzene-1,2,4-tricarboxylate, trioctyl ester, C8TM, CAS no. 89-04-3; corresponding to 108 mg/L of the target substance). Furthermore, no mortality was observed in the supporting study (EU Method C.1, GLP, Huels AG, 1994, RL2) in a limit test at 3 mg/L test substance (analogue substance: 1,2,4 -benzenetricarboxylic acid, mixed decyl and octyl triesters, C8C10TM, CAS no. 90218-76-1; corresponding to 3 mg/L of the target substance). In conclusion, no acute toxicity to fish is expected below the water solubility of the submission substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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