Registration Dossier
Registration Dossier
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EC number: 248-697-2 | CAS number: 27858-32-8
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
Substance decomposes during vapour pressure testing (OECD104). Because of rapid hydrolysis, vapour pressure of isopropyl alcohol released from the substance is used in CSA.
Key value for chemical safety assessment
- Vapour pressure:
- 60.2 hPa
- at the temperature of:
- 25 °C
Additional information
The isothermal TGA effusion method by using OECD 104 in accordance with GLP was applied for the determination of the vapour pressure of the substance. The vapour pressure could not be determined as the test substance decomposes.
This substance is hydrolytically unstable (half-life < 10 minutes; OECD 111). When it comes in contact with water or moisture a complete hydrolysis will take place with no significant reaction products other than isopropyl alcohol and ethyl acetoacetate and insoluble hydrated titanium oxides.
Because of rapid hydrolysis, the CSA concentrates on the most hazardous degradation product which is isopropyl alcohol. Because of rapid hydrolysis, read-across data on the vapour pressure of isopropyl alcohol released from the substance is used as a key value in CSA (peer-reviewed handbook value, Lide 2000). The other degradation products ethyl acetoacetate and hydrated titanium dioxide are not further considered in the chemical safety assessment as they are non-hazardous to human health.
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