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Diss Factsheets
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EC number: 241-620-3 | CAS number: 17636-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation:
1-Propanesulfonic acid, 3-mercapto-, monosodium salt (MPS) was investigated for its sensitising potential based on the buehler test procedure (deviations: only 15 test animals, open epicutaneous application, 3 times 5 daily applications, same dose in induction and challenge) in guinea pigs (Dickhaus and Heisler, 1987). The test included three phases: induction phase, when test material is applied to hair free skin of test animals openly on the epidermis for a total of fifteen applications; two-week rest period during which an immune response may develop and challenge phase during which the immune system if sensitised reacts hypersensitive (2 applications in a 24 hour rhythm).0.5 g of test material moistened with sterile water was used in the induction phase and in the challenge phase. Treated skin sites were scored according scale as described in the Buehler test method. 24, 48 and 72-hour readings were performed after the challenge applications. No skin reactions were noted at the treated sites of the test or control group animals at the 24 or 48 -hour reading. In conclusion, no skin reactions were observed and therefore the substance is considered to be not sensitising.
The deviations are not considered to bear the potential to miss a inherited potential to act as a sensitiser. Therefore the results of this study are considered to be reliable and valid.
Prediction using TOXTREE
According to the results of TOXTREE modelling tool, 1-Propanesulfonic acid, 3-mercapto-, monosodium salt is estimated to be negative for skin sensitisation potential. The test substance is not electrophile reactive. No structural alerts are identified for the possibility of nucleophilic substitution, Shiff base formation or addition-elimination reactions. There are no functional groups which can act as Michael acceptors.
Migrated from Short description of key information:
1987, in vivo guinea pig, similar to buehler test (OECD 406), not sensitising
Justification for classification or non-classification
Under the conditions of the test, the test material produced a 0% sensitisation rate and was classified as a non-sensitiser to guinea pig skin.
The test material did not meet the criteria for classification as a sensitiser according to EU labelling regulations Commission Directive 93/21 /EEC. No symbol and risk phrase is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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