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EC number: 234-465-8 | CAS number: 12005-21-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance pentaaluminium triyttrium dodecaoxide is not irrittaing to the skin and not irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-12-13 to 2011-01-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, 97633 Sulzfeld, Germany
- Age at study initiation: ca. 24 weeks
- Weight at study initiation: 4.4 kg, 4.3 kg, 4.8 kg
- Housing: Semi barrier in an air-conditioned room, housed in ABS - plastic rabbit cages, floor 4200 cm2
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3°C
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 2010-12-08 To:2010-12-20 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- other: The untreated right body sight served as control. In order to confirm the negative response, two additional animals were treated with a patch without the test item.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): enough for moistening the test item
- Purity: ca. 100 % - Duration of treatment / exposure:
- Initial test: 4h
Main test: 4 h - Observation period:
- The animals were examined for signs of erythema and oedema 1 h after the patch removal. For the determination of classification-relevant values, the animals were examined for signs of erythema and oedema 24, 48 and 72 hours after the patch removal.
- Number of animals:
- Initial test: 1
Main test: 3 - Details on study design:
- TEST SITE
- Area of exposure: ca. 6 cm²
- Type of wrap if used: semi-occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 72 h
SCORING SYSTEM: Erythema and eschar formation, oedema form - Irritation parameter:
- erythema score
- Basis:
- other: animals 2 and 3
- Time point:
- other: 1 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: animals 2 and 3
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: animals 2 and 3
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other: animals 2 and 3
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 1 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 1h
- Score:
- 0
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: animals, 1, 2 and 3
- Time point:
- other: 24 h
- Score:
- 0
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: animals 1,2 and 3
- Time point:
- other: 48 h
- Score:
- 0
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- other: systemic findings, specific local findings
- Basis:
- other: animals 1, 2 and 3
- Time point:
- other: 72 h
- Score:
- 0
- Remarks on result:
- other: no systemic findings, no specific local findings
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Initial test.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 0
- Remarks on result:
- other: Initial test.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48 h
- Score:
- 0
- Remarks on result:
- other: Initial test.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72 h
- Score:
- 0
- Remarks on result:
- other: Iniital test.
- Irritant / corrosive response data:
- The initial test in animal no.1: The examination of the test site immediately after the patch removal revealed erythema grade 1, the subsequent clinical observation showed erythema grade 1 after 1 h, but no corrosive effects.
The test item showed neither irritant nor corrosive effects on the intact skin in the other 2 animals at any time. - Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not irritant, not corrosive.
- Executive summary:
Under the conditions of the study the single dermal application of the test item L181 to rabbits at a dose of 0.5 g showed slightly irritant but no corrosive effects in one animal, which were fully reversible within 24 h.
Neither mortalities nor significant clinical signs of toxicity were observed.
In conformity with the criteria for classification and labeling requirements of the CLP-regulation 1272/2008 (as well as the DSD 2001/59/EC), the test item L181 does not have to be classified and has no obligatory requirement for skin irritation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The variation L181 was tested for the potential to cause skin irritation in a GLP guideline studies according to OECD 404.
The substance did not exhibit skin irritation or skin corrosion.
The same profile is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
The variations L181 and L175G25C4G were tested for the potential to cause eye irritation in a GLP guideline studies according to OECD 405.
Both variations did not exhibit eye irritation or eye corrosion.
The results of the 2 studies on eye irritation reveal the same profile for both variations. The same result is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
Justification for selection of eye irritation endpoint:
Both studies were selected.
Justification for classification or non-classification
Pentaaluminium triyttrium dodecaoxide did not show any potential to cause dermal irritation or dermal corrosion.
Pentaaluminium triyttrium dodecaoxide did not show any potential to cause eye irritation or eye corrosion.
C&L is not required.
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