Registration Dossier
Registration Dossier
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EC number: 233-071-3 | CAS number: 10028-18-9
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
High quality studies are available in the database of chronic toxicity to fish. A lumped data set for nickel-based compounds was considered for endpoint coverage. The lowest NOEC or EC10 value was identified as 40 µg Ni/L for freshwater fish and 3.6mg Ni/L for marine fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.04 mg/L
Marine water fish
Marine water fish
- Dose descriptor:
- EC10
- Effect concentration:
- 3.6 mg/L
Additional information
Fresh Water ion Nickel
High quality NOEC/L(E)C10values for chronic toxicity to freshwater fish are based on the fish species, Pimephales promelas, Oncorhynchus mykiss, and Brachydanio rerio. The NOEC/L(E)C10 values for fish range from 40 μg/l for Brachydanio rerio (Dave & Xiu, 1991) to 15420 μg/l for the Brachydanio rerio (Kienle et al., 2009).
The following table indicates those NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation.
Key Study (freshwater Fish) | Selected values for the most sensitive endpoints used for derivation of the freshwater HC5 | ||
Species | Endpoint | Value (ug/L) | |
Birge et al., 1984 | Pimephales promelas | NOEC | 57 |
Nebeker et al., 1985 | Oncorhynchus mykiss | NOEC | 134 |
Dave & Xiu., 1991 | Brachydanio rerio | NOEC | 40 |
Fresh Water ion Fluoride
Among valid data in the literature, Shi et al. (2009) found the lowest NOEC in fish in 90 days in Acipenser baerii (sturgeon): 4 mg F-/L (measured). The contribution from fluoride ion is considered to be negligible.
CONCLUSION NOEC 40 µg/L Ni (= NOEC 66 µg/l NiF2)
Marine Water ion Nickel
Chronic toxicity values are reported for two marine fish species. EC10 values range from 3.6 mg Ni/L for growth of the topsmelt, Atherinops affinis (Hunt et al., 2002), to 20.8 mg Ni/L for growth of the sheepshead minnow, Cyprinodon variegatus (Golder et al., 2007).
The following table indicates those NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation.
Key Study (marine Fish) | Selected values for the most sensitive endpoints used for derivation of the marine HC5 | ||
Species | Endpoint | Value (ug/L) | |
Golder, 2005 | Cyprinodon variegatus | EC10 | 20,760 |
Hunt et al., 2002 | Atherinops affinis | EC10 | 3,599 |
Marine Water ion Fluoride
The worst-case NOEC of 113d on juvenile development was determined to be 5.5 mg/L (Mugil cephalus). The contribution from fluoride ion is considered to be negligible.
CONCLUSION NOEC 3.6 mg/L Ni (= NOEC 5.9 mg/l NiF2)
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