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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation
The test substance is irritating to skin according to the DSD and CLP.
The exposure caused moderate to severe erythema and oedema according to the Draize test after 24 h of skin contact. After 72 h, a primary dermal irritation index of 4.5 was calculated
Eye irritation
Stoddard solvent was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 7 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.22. Irritation subsided and all animals were clear of ocular irritation within 7 days after treatment. The mean corneal opacity, iris lesion and conjunctivae redness, scores were 0.05, 0.05 and 0.22, respectively. These findings do not warrant classification of Stoddard solvent as an ocular irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations Result: not irritating at 0.1 mL.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Stoddard solvent (14.5% aromatics) CAS (8052-41-3) Boiling Point Range 160-199 °C
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Age at study initiation: 3-5 months
- Weight at study initiation: 2.6-3.5 kg
- Housing: individual cages, identified with ear tags
- Diet (e.g. ad libitum): Altromin 2123 Haltungsdiat ad libitum, 15 g/day
- Water (e.g. ad libitum): deionized water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 degree C
- Humidity (%): 50 +/- 20 %
- Photoperiod (hrs dark / hrs light): 12/12 hrs - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- Observations were made at 24 and 72 hrs after end of exposure.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: dorsal trunk area
- % coverage: 2.5 x 2.5 cm area
- Type of wrap if used: cellulose bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): removed with lukewarm water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Draize scale - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 4.5
- Reversibility:
- not specified
- Remarks on result:
- other: moderate to severe irritant; edema after 24 hrs
- Irritant / corrosive response data:
- The exposure caused moderate to severe erythema and oedema according to the Draize test after 24 h of skin contact. After 72 h, a primary dermal irritation index of 4.5 was calculated
- Other effects:
- Microscopic examination showed hardening of the skin, hyperkeratosis, and misalignment with nearby skin.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test substance is irritating to skin according to the DSD and CLP.
The exposure caused moderate to severe erythema and oedema according to the Draize test after 24 h of skin contact. After 72 h, a primary dermal irritation index of 4.5 was calculated - Executive summary:
In a test for primary dermal irritation, 0.5 ml of Stoddard solvent (14.5% aromatics) was applied to the shaved (abraded and nonabraded) skin of six male New Zealand White rabbits. The exposed area was covered with an occlusive dressing for 24 h. The exposure caused moderate to severe erythema and oedema according to the Draize test after 24 h of skin contact. After 72 h, a primary dermal irritation index of 4.5 was calculated
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Application of 200, 1000 and 2000 mg/kg of white spirit (Stoddard solvent) to the shaved intact skin (15 × 20 cm2) of 10 New Zealand White rabbits 3 times a week for 4 weeks
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Stoddard solvent (14.5% aromatics) CAS (8052-41-3) Boiling Point Range 160-199 °C
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG
- Age at study initiation: 3-5 months
- Weight at study initiation: 2.6-3.5 kg
- Housing: individual cages, identified with ear tags
- Diet (e.g. ad libitum): Altromin 2123 Haltungsdiat ad libitum, 15 g/day
- Water (e.g. ad libitum): deionized water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 degree C
- Humidity (%): 50 +/- 20 %
- Photoperiod (hrs dark / hrs light): 12/12 hrs - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Application of 200, 1000 and 2000 mg/kg of white spirit (Stoddard solvent) to the shaved intact skin (15 × 20 cm2) of 10 New Zealand White rabbits 3 times a week for 4 weeks
- Duration of treatment / exposure:
- 28 days
- Observation period:
- 28 days
- Number of animals:
- 10
- Details on study design:
- Application of 200, 1000 and 2000 mg/kg of white spirit (Stoddard solvent) to the shaved intact skin (15 × 20 cm2) of 10 New Zealand White rabbits 3 times a week for 4 weeks resulted in a dose-related increase in irritation response (Draize testing). Following the application, the test site was occluded for 6 h with a gauze pad and a sheet of polyethylene.
SCORING SYSTEM: Draize scale - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 28 d
- Score:
- 4.5
- Reversibility:
- not specified
- Remarks on result:
- other: "Moderate irritation" was observed at the lowest dose level and "severe irritation" at the highest dose level
- Irritant / corrosive response data:
- The exposure caused moderate to severe erythema and oedema according to the Draize test after 3 times a week for 4 weeks of skin contact.
- Other effects:
- Microscopic examination showed hardening of the skin, hyperkeratosis, and misalignment with nearby skin.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test substance is irritating to skin according to the DSD and CLP.
The exposure caused moderate to severe erythema and oedema according to the Draize test after 3 times a week for 4 weeks of skin contact. - Executive summary:
Application of 200, 1000 and 2000 mg/kg of white spirit (Stoddard solvent) to the shaved intact skin (15 × 20 cm2) of 10 New Zealand White rabbits 3 times a week for 4 weeks resulted in a dose-related increase in irritation response (Draize testing). Following the application, the test site was occluded for 6 h with a gauze pad and a sheet of polyethylene. "Moderate irritation" was observed at the lowest dose level and "severe irritation" at the highest dose level
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Stoddard solvent CAS (8052-41-3)
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- Observations were made at 24 hrs after end of exposure.
- Number of animals:
- 6
- Details on study design:
- The application site was covered with gauze and an elastic bandage for a duration of 24 h.
SCORING SYSTEM: Draize scale - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1.55
- Reversibility:
- not specified
- Remarks on result:
- other: minor signs of irritation after 24 hrs
- Irritant / corrosive response data:
- The exposure caused minor signs of irritation according to the Draize test after 24 h of skin contact. After 24 h, a primary dermal irritation index of 1.55 was calculated
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- The test substance is mild irritant to skin according to the GHS criteria.
In a skin irritation test with New Zealand White rabbits exposed to white spirit (Stoddard solvent), was only minor signs of irritation and hence calculated an index of 1.55. - Executive summary:
In a skin irritation test with New Zealand White rabbits exposed to white spirit (Stoddard solvent), was only minor signs of irritation and hence calculated an index of 1.55. The application site was covered with gauze and an elastic bandage for a duration of 24 h.
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Test substance was applied to 2 different sites for 4 hrs and residual material was removed from site using water vs. white oil.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- C9-C12 Mixed aliphatic and aromatics (8052-41-3) Boiling Point Range 158-204 °C
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sittingbourne Research Centre breeding colony
- Age at study initiation: 3 to 6 months
- Weight at study initiation: 3.4 kg to 4.9 kg
- Housing: Individual- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 to 19 °C
- Humidity (%): monitored- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL undiluted applied to 2 different sites for 4 hrs; - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- Observations were made at 24,48 and 72 hrs after end of exposure.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
-0.5 mL undiluted applied to 2 different sites for 4 hrs;
semi-occlusive patch;
residual material removed from site using water vs. white oil
SCORING SYSTEM: Scale of 0 to 4 for both erythema and edema - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.94
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: Mean 24, 48, 72 hr scores (water-wiped site) Erythema 1.94
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.56
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Mean 24, 48, 72 hr scores (water-wiped site) Edema 0.56;
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.05
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Mean 24, 48, 72 hr scores (oil-wiped site) Erythema 2.05;
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: Mean 24, 48, 72 hr scores (oil-wiped site) Edema 0.67
- Irritant / corrosive response data:
- The group mean 24, 48, and 72 hour scores (water-wiped site) for erythema and edema were 1.94 and 0.56 respectively.
The group mean 24, 48, and 72 hour scores (oil-wiped site) for erythema and edema were 2.05 and 0.67 respectively.
Under the conditions of this study, the test material was classified as not irritating according to EU criteria. - Interpretation of results:
- other: not irritating
- Conclusions:
- The group mean 24, 48, and 72 hour scores (water-wiped site) for erythema and edema were 1.94 and 0.56 respectively.
The group mean 24, 48, and 72 hour scores (oil-wiped site) for erythema and edema were 2.05 and 0.67 respectively.
Under the conditions of this study, the test material was classified as not irritating according to EU criteria. - Executive summary:
In a skin irritation study, three male and three female rabbits were treated with 0.5 mL of undiluted test material. The test material was applied to 2 different sites for 4 hrs and residual material was removed from site using water vs. white oil. The group mean 24, 48, and 72 hour scores (water-wiped site) for erythema and edema were 1.94 and 0.56 respectively. The group mean 24, 48, and 72 hour scores (oil-wiped site) for erythema and edema were 2.05 and 0.67 respectively. Under the conditions of this study, the test material was classified as not irritating according to EU criteria.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- C9-C12 Mixed aliphatics and aromatics (8052-41-3) Boiling Point (C) 160-199
(Stoddard solvent; 14.5% aromatics) - Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes - Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritant / corrosive response data:
- No or only very slight irritation occurred after the application of 0.1 ml of Stoddard solvent to the eyes of six rabbits. One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
- Interpretation of results:
- other: not irritating
- Conclusions:
- The eyes of six rabbits were treated with the test substance and observed for 7 days. Results indicate that the substance was not irritating .
One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
Result: not irritating at 0.1 mL. - Executive summary:
No or only very slight irritation occurred after the application of 0.1 ml of Stoddard solvent to the eyes of six rabbits. One hour after application one of the rabbits showed mild injection and swelling of the conjunctiva. However, these signs of irritative response disappeared after 24 h
- Endpoint:
- eye irritation, other
- Remarks:
- The test substance was applied into the one eye and a saline solution was applied into the other eye as a control.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- C8-C13 Mixed aliphatics and aromatics (8052-41-3) Boiling Point (C) 154-189
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes - Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: Non-irritant
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.05
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.05
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Stoddard solvent was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 7 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.22. Irritation subsided and all animals were clear of ocular irritation within 7 days after treatment. The mean corneal opacity, iris lesion and conjunctivae redness, scores were 0.05, 0.05 and 0.22, respectively. These findings do not warrant classification of Stoddard solvent as an ocular irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations
- Interpretation of results:
- other: not irritating
- Conclusions:
- Stoddard solvent was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 7 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.22. Irritation subsided and all animals were clear of ocular irritation within 7 days after treatment. The mean corneal opacity, iris lesion and conjunctivae redness, scores were 0.05, 0.05 and 0.22, respectively. These findings do not warrant classification of Stoddard solvent as an ocular irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations
Result: not irritating at 0.1 mL. - Executive summary:
Stoddard solvent was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 7 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.22. Irritation subsided and all animals were clear of ocular irritation within 7 days after treatment. The mean corneal opacity, iris lesion and conjunctivae redness, scores were 0.05, 0.05 and 0.22, respectively. These findings do not warrant classification of Stoddard solvent as an ocular irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations
Result: not irritating at 0.1 mL.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The test substance is irritating to skin according to the DSD and CLP.
The exposure caused moderate to severe erythema and oedema according to the Draize test after 24 h of skin contact. After 72 h, a primary dermal irritation index of 4.5 was calculated
Eye irritation
Stoddard solvent was administered to one eye of six New Zealand White rabbits to assess for ocular irritation. Observations were made at 24, 48 and 72 hours and 7 days after treatment. Ocular damage was assessed and scored according to the Draize eye test. Ocular irritation was most prominent at the 48 and 72 hour observation period receiving a Draize score of 0.22. Irritation subsided and all animals were clear of ocular irritation within 7 days after treatment. The mean corneal opacity, iris lesion and conjunctivae redness, scores were 0.05, 0.05 and 0.22, respectively. These findings do not warrant classification of Stoddard solvent as an ocular irritant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations Result: not irritating at 0.1 mL.
Justification for classification or non-classification
Based on the hazard assessment of Stoddard solvent, in section 2.1 and 2.2. in IUCLID 6., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health”, according to the EU’s list of dangerous substances (OJEC No L200/130.7.99) and according to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Skin Corrosivity C R35 Causes severe burns R34 Causes burns Skin Irritation Xi R38 Irritating to skin R43 May cause sensitization by skin contact Eye Irritation (Ocular Lesions) Xi R36 Irritating to eyes R37 irritating to respiratory system R41 Risk of serious damage to eyes |
CLP |
Skin Corrosivity H314 Skin Corr 1A Causes severe skin burns and eye damage H314 Skin Corr 1B Causes severe skin burns and eye damage Skin Irritation H315 Skin Irrit. 2 Causes skin irritation H317 Skin Sens. 1 May cause an allergic skin reaction Eye Irritation (Ocular Lesions) Xi H319 Eye Irrit. 2 Causes serious eye irritation H318 Eye Dam. 1 Causes serious eye damage H335 STOT SE 3 May cause respiratory irritation
|
It is concluded that the substance Stoddard solvent meet the criteria to be classified for human health hazards for Skin Irritation and does not meet for Eye Irritation and does not meet for respiratory irritation:
R38 Irritating to skin
H315 Skin Irrit. 2 Causes skin irritation,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.