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Diss Factsheets
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EC number: 231-749-3 | CAS number: 7719-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Older proprietary studies of toxicity by the oral, dermal and inhalation routes are available. Supporting published data are also available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 18 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 592 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 260 mg/kg bw
Additional information
Acute oral toxicity
The acute oral LD50 of phosphorus trichloride was found to be 200 mg/kg bw and 540 mg/kg bw in the rat in older proprietary studies comparable to OECD 401 (Terrell, 1977; Lesit & Weigand, 1978). A further published study (Molodkina, 1973) reports an LD50 value of 550 mg/kg bw. However a much lower value of 18.0 mg/kg bw was determined in another study (Randall & Robinson, 1990). The wide variation in acute oral LD50 values may be a consequence of the dose vehicle: vegetable/corn oil was used as a vehicle in the studies of Terrell and Molodkina, however the study of Randall & Robinson did not use a dosing vehicle. The consequent rapid and violent reaction of the test substance in the stomach may therefore potentiallty have caused much greater toxicity.
Acute inhalation toxicity
In a proprietary acute inhlation toxicity study (Cannon, 1977), no deaths (0/10) occurred in rats exposed to a nomimal exposure concentration of 20.29 mg/L. However the study is not considered to be sufficiently reliable in the absence of any analytical data on the exposure concentration. An additonal published study by Molodkina (1973) reported an analytical LC50 of 0.22 mg/L. An additional study (Hollander & Mayer, 1977) reported mortaility in rats exposed for very brief periods. A good quality published study (Weeks et al, 1964) reports analytical LC50 values for 4 -hour exposures of 0.592 mg/l in rats and 0.285 mg/l in guinea pigs.
Acute dermal toxicity
In the acute dermal toxicity study in the rabbit (Imlay, 1977), no deaths occurred at a dose level of 250 mg/kg bw (0/13 animals tested), however the single animal tested at 500 mg/kg bw died. Based on the results of this study, the acute dermal LD50 of the substance is calculated to be between 250 -500 mg/kg bw, but is considered likely to be closer to 500 mg/kg bw. In a further rabbit study, the acute dermal LD50 was calculated to be 1260 mg/kg bw.
Justification for classification or non-classification
Phosphorus trichloride is listed on Annex I of the Dangerous Substances Directive (67/548/EEC) with classification as (R28) 'Very toxic if swallowed' and (R26) 'Very toxic by inhalation'. No change to this classification is proposed on the basis of the available data.
On the basis of the studies reported (dermal LD50 of 1260 mg/kg bw), classification with (R21) 'Harmful in contact with skin' is also proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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