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EC number: 225-791-1 | CAS number: 5080-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 36
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 8.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 72
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 31.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
ISOPROPYLHYDROXYLAMINE
N-isopropylhydroxylamine (IPHA) is a primary alkylhydroxylamine that has shown excellent performance as a shortstop for styrene-butadienepolymerization. It is also used as an oxygen scavenger and metal passivator to inhibit corrosion in boiler water systems.
The following DNELs were derived using ECETOC guidance document entitled, “Guidance on Assessment Factors to Derive DNELs” Final draft. March 17th 2010.
WORKER POPULATION:
Dermal DNEL: Acute/Short-Term worker population exposure systemic effects
A NOAEL from an oral 28 day study in rats exposed to IPHA was used to derive a dermal DNEL acute/short term exposure systemic effects.
Dose Modification:
Corrected dermal NOAEL = Oral NOAEL x Abs (oral rat)/Abs (dermal human) = [ 100%/Abs 7.4 % = 13.5]
Dermal Absorption taken from Dermwin the predicted relative dermal absorption of aqueous solution of IPHA ranged from 3.5% to 7.4%.
Therefore: 20 mg/kg/day x 13.5 = 270 mg/kg/day
Worker adjustment 7 day/week to 5 day week = 7/5
Modified Dose: (270 mg/kg/day x 7)/5 = 378mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = N/A
Intraspecies adjustment factor for the worker population = 3
Exposure Duration (Subacute study) = N/A
WorkerPopulation dermal DNEL Acute/Short-Term Exposure Systemic Effects = 378 mg/kg/day/(4*3) =31.5 mg/kg/day
Inhalation DNEL: Acute/Short-term worker population exposure systemic effects
The NOEL of 20 mg/kg was taken from a sub-chronic study to derive an inhalation DNEL/worker population.
Modification Factors:
Physiological Parameters = 0.38 m3/kg bw (See Table R. 8.2)
Inhalation adjustment = (20 mg/kg)/(0.38 m3/kg bw) = 52.6 mg/m3
Then 52.6 mg/m3x (6.7 m3/10 m3) = 35.3 mg/m3
Then (35.3 mg/m3) x (7/5) = 49.4 mg/m3
Assessment factors:
Assessment factor for route-to-route extrapolation when considering oral to inhalation. = 2
Remaining Differences = N/A
Subchronic to Acute = N/A
Intraspecies variation for the worker population = 3
Inhalation DNEL: Acute/Short-term worker population exposure systemic effects =
(49.4 mg/m3)/(2 x 3) =8.2 mg/m3
Dermal DNEL: Long-Term worker population exposure systemic effects
A NOAEL from an oral 28 day study in rats exposed to IPHA was used to derive a dermal DNEL long- term exposure systemic effects.
Dose Modification:
Corrected dermal NOAEL = Oral NOAEL x Abs (oral rat)/Abs (dermal human) = [ 100%/Abs 7.4 % = 13.5]
Dermal Absorption taken from Dermwin the predicted relative dermal absorption of aqueous solution of IPHA ranged from 3.5% to 7.4%.
Therefore: 20 mg/kg/day x 13.5 = 270 mg/kg/day
Worker adjustments 7 day/week to 5 day week = 7/5
Modified Dose: (270 mg/kg/day) x (8/24) (7/5) = 378 mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = N/A
Intraspecies adjustment factor for the worker population = 3
Exposure Duration (Subacute to Chronic study) = 6
Worker Population dermal DNEL Acute/Short-Term Exposure Systemic Effects = 378 mg/kg/day/(4*3*6)= 5.25 mg/kg/d
Inhalation DNEL: /Long-term worker population exposure systemic effects
The NOEL of 20 mg/kg was taken from a sub-chronic oral study to derive an inhalation DNEL/worker population.
Modification Factors:
Physiological Parameters = 0.38 m3/kg bw (See Table R. 8.2)
Inhalation adjustment = (20 mg/kg)/(0.38 m3/kg bw) = 52.6 mg/m3
Then 52.6 mg/m3 x (6.7 m3/10 m3) = 35.3 mg/m3
Then (35.3 mg/m3) x (7/5) =49.4 mg/m3
Assessment factors:
Assessment factor for route-to-route extrapolation when considering oral to inhalation. = 2
Remaining Differences = N/A
Subchronic to Acute = 6
Intraspecies variation for the worker population = 3
Inhalation DNEL: Acute/Short-term workerpopulation exposure systemic effects =
(49.4 mg/m3)/(2 x 3 x 6) =1.4 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
N-isopropylhydroxylamine (IPHA) is for used in industry as a shortstop for styrene-butadienepolymerization. It is also used as an oxygen scavenger and metal passivator to inhibit corrosion in boiler water systems. It is mainly for industrial uses and some minor professional uses. No consumer uses have been identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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