Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-339-0 | CAS number: 4316-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- The bioaccumulation is estimated using the log BCF (regression based estimate), Biotransformation Half-Life and the log BAF (Arnot-Gobas upper trophic) by BCFBAF v3.01, using EPI Suite.
- Principles of method if other than guideline:
- The bioaccumulation is estimated using the log BCF (regression based estimate), Biotransformation Half-Life and the log BAF (Arnot-Gobas upper trophic) by BCFBAF v3.01.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Calculation is based on the structure of N-methyltaurinate
- Name of test material (as cited in study report): Ethanesulfonic acid, 2- (methylamino)-, monosodium salt - Details on estimation of bioconcentration:
- Log BCF = 0.50 (Ionic; Log Kow dependent)
- Type:
- BCF
- Value:
- 3.16 L/kg
- Remarks on result:
- other: Regression-based estimate
- Type:
- BAF
- Value:
- 0.893 L/kg
- Remarks on result:
- other: Arnot-Gobas upper trophic
- Parameter:
- DT50
- Depuration time (DT):
- 0.008 d
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The bioaccumulation potential of sodium N-methyltaurinate is low according to the estimation by calculation. The estimated BCF is 3.16 L/kg, BAF is 0.893 L/kg and biotransformation half-life is 0.00825 days.
- Executive summary:
The bioaccumulation potential of sodium N-methyltaurinate is low according to the estimation by calculation. The BCF estimation is 3.16 L/kg, BAF is 0.893 L/kg and biotransformation half-life is 0.00825 days. Nevertheless, the EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. However, empirical studies have not been done, so that we adopt the prediction.
Reference
Whole Body Primary Biotransformation Rate Estimate for Fish: | ||||
Type | Num | Log biotransformation fragment description | Coeff | Value |
Frag | 1 | Aliphatic amine [-NH2 or -NH-] | 0.4067 | 0.4067 |
Frag | 1 | Sulfonic acid / salt -> aliphatic attach | 0.0000 | 0.0000 |
Frag | 1 | Methyl [-CH3] | 0.2451 | 0.2451 |
Frag | 2 | -CH2- [linear] | 0.0242 | 0.0484 |
L Kow | * | Log Kow = -2.90 (estimate) | 0.3073 | -0.8900 |
MolWt | * | Molecular weight parameter | -0.3569 | |
Const | * | Equation constant | -1.5058 | |
Result | Log Bio Half-Life (days) | -2.0837 | ||
Result | Bio Half-Life (days) | 0.008247 | ||
Bio Half-Life Normalized to 10 g fish at 15 deg C |
Biotransformation Rate Constant:
kM (Rate Constant): 84.05 /day (10 gram fish)
kM (Rate Constant): 47.26 /day (100 gram fish)
kM (Rate Constant): 26.58 /day (1 kg fish)
kM (Rate Constant): 14.95 /day (10 kg fish)
Arnot-Gobas BCF & BAF Methods (including biotransformation rate estimates):
Estimated Log BCF, Log BAF (upper trophic) = -0.049 (BCF, BAF = 0.893 L/kg wet-wt)
Estimated Log BCF, Log BAF (mid trophic) = -0.031 (BCF, BAF = 0.9315 L/kg wet-wt)
Estimated Log BCF, LOG BAF (lower trophic) = -0.027 (BCF, BAF = 0.9402 L/kg wet-wt)
assuming a biotransformation rate of zero:
Estimated Log BCF, Log BAF (upper trophic) = -0.049 (BCF, BAF = 0.893 L/kg wet-wt)
Description of key information
The estimation by calculation for the BCF is 3.16 L/kg, reflecting low bioaccumulation potential of sodium N-methyltaurinate.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.16 L/kg ww
Additional information
The bioaccumulation potential of sodium N-methyltaurinate is low according to the estimation by calculation. The BCF estimation is 3.16 L/kg, BAF is 0.893 L/kg and biotransformation half-life is 0.00825 days. Nevertheless, the EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. However, empirical studies have not been done, so that we adopt the prediction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.