Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-621-2 | CAS number: 2835-99-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC of 4 -amino-m-cresol for adult survival, time of the first brood and juveniles produced per surviving parent, and adult growth are equal to 0.22 mg/L in a 21-day Daphnia magna reproduction study OECD 211.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.22 mg/L
Additional information
A 21-day Daphnia magna reproduction study was conducted to determine the effects of exposure to the test substance 4-amino-m-cresol on Daphnia magna reproduction. The study was conducted in accordance with the OECD Chemicals Testing Guideline No.211 Daphnia magna Reproduction Test (adopted October 2012) and GLP.
The definitive test was conducted at nominal concentrations of 0.0056, 0.018, 0.056, 0.18 and 0.56 mg/L. A control group was also included. The test was conducted using a semi-static design with daily renewal of the test media.
Ten replicate test vessels were prepared for the control and each test concentration. A single juvenile Daphnia magna (<24 hours old) was added to each test vessel.
On renewal occasions, parental animals were transferred into freshly prepared test media. Any juveniles remaining in old test media were counted and the number of juveniles produced per parental animal on any day during the 21-day study duration was recorded. At the end of the test, carapace lengths of all surviving parental Daphnia magna were measured.
Chemical analysis of the freshly prepared media showed measured concentrations to range from 80% to 120% of nominal value with the exception of the 0.018 and 0.56 mg/L test concentrations on Day 0 which showed measured concentrations of 121% of nominal value. However, as the measured concentration was only just above the 120% acceptance limit these results were not considered to affect the
validity of the test. Analysis of the old media showed measured concentrations to range from less than the limit of quantification (LOQ) of the analytical method (assessed as 0.002 mg/L) to 19% of nominal.
Given the decline in measured concentration over each 24-hour renewal period, it was considered justifiable to base the results on time-weighted mean measured test concentrations. These were calculated to be 0.0028, 0.0061, 0.017, 0.069 and 0.22 mg/L.
The NOEC and LOEC of 4-amino-m-cresol in term of adult survival, time of the first brood and juveniles produced per surviving parent, and adult growth are 0.22 mg/L and > 0.22 mg/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.