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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
REPORTING FORMAT FOR THE CATEGORY APPROACH
See 2018_Read-across-Justification_V1 in attached justification

1. HYPOTHESIS FOR THE CATEGORY APPROACH (ENDPOINT LEVEL)
See 2018_Read-across-Justification_V1 in attached justification

2. CATEGORY APPROACH JUSTIFICATION (ENDPOINT LEVEL
See 2018_Read-across-Justification_V1 in attached justification
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
ca. 0.64 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Remarks on result:
other: Based on other substance (read-across)
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 0.55 - < 0.76 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mobility
Remarks on result:
other:
Remarks:
Based on other substance (read-across)
Validity criteria fulfilled:
yes
Conclusions:
Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:
- Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
- hexadecyldimethylamine N-oxide – CAS 7128-91-8
- Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6
These data indicate:
- The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
- The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
- The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.
On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L.
Executive summary:

Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:

  • Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
  • hexadecyldimethylamine N-oxide – CAS 7128-91-8
  • Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6

These data indicate:

  • The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
  • The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
  • The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.

On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L.

Description of key information

Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:

  • Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
  • hexadecyldimethylamine N-oxide – CAS 7128-91-8
  • Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6

These data indicate:

  • The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
  • The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
  • The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.

On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.64 mg/L

Additional information