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EC number: 219-919-5 | CAS number: 2571-88-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- REPORTING FORMAT FOR THE CATEGORY APPROACH
See 2018_Read-across-Justification_V1 in attached justification
1. HYPOTHESIS FOR THE CATEGORY APPROACH (ENDPOINT LEVEL)
See 2018_Read-across-Justification_V1 in attached justification
2. CATEGORY APPROACH JUSTIFICATION (ENDPOINT LEVEL
See 2018_Read-across-Justification_V1 in attached justification - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: Based on other substance (read-across)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.55 - < 0.76 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Based on other substance (read-across)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:
- Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
- hexadecyldimethylamine N-oxide – CAS 7128-91-8
- Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6
These data indicate:
- The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
- The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
- The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.
On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L. - Executive summary:
Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:
- Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
- hexadecyldimethylamine N-oxide – CAS 7128-91-8
- Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6
These data indicate:
- The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
- The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
- The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.
On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L.
Reference
Description of key information
- Dihydroxyethyl oleamine oxide - CAS 93962-62-0,
- hexadecyldimethylamine N-oxide – CAS 7128-91-8
- Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides – CSA 61791-46-6
- The mean EC50, 48 hours is 0.64 mg AO/L [0.55 – 0.76] for Dihydroxyethyl oleamine oxide.
- The mean EC50, 48 hours is 0.65 mg AO/L [0.58 – 0.73] for hexadecyldimethylamine N-oxide.
- The mean EC50, 48 hours is 0.47 mg AO/L [0.38 – 0.59] for Ethanol, 2,2'-iminobis-, N-tallow alkyl derivs., N-oxides.
Concerning the read-across approach in the IUCLID file, the data on three other C16-18 Amine Oxide was used as Source study:
These data indicate:
On the basis of this data, the EC50, 48 hours of N,N-Dimethyl-1-octadecanamine-N-oxide is 0.59 mg AO/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.64 mg/L
Additional information
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