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EC number: 219-154-7 | CAS number: 2374-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2,4,6-Trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane (F-D3) is a mono-constituent substance where the main constituent (trans geometric isomer) is present at concentrations≥72% w/w, and a named impurity (the cis geometric isomer) may be present at concentrations ≥0% -≤28% w/w.
F-D3 may be a solid or liquid substance at room temperature depending on the proportion of the geometric isomers. The melting point is influenced by the isomer in highest proportion; the trans form (99.5% purity) has a measured melting point of 35°C, when the form is 96% cis, the melting point is -1.9°C and at 85% cis, the melting point is approximately -7°C.
The substance has a predicted boiling point of 190°C and a predicted density of 1.2 g/cm3 at 20°C. F-D3 has a measured vapour pressure of 75.6 Pa and 88 Pa at 20°C and 25°C respectively and a predicted kinematic viscosity of 3.3 mm2/s at 20°C.
The substance is a liquid or low melting point solid depending on the ratio of the geometric isomers present. The flammability is therefore assessed based on available flash point data. F-D3 is not classified as a flammable liquid according to Regulation (EC) No. 1272/2008, on the basis of a measured flash point of 124°C at 100.6 kPa and predicted boiling point of 190°C. It has a measured auto-ignition temperature of 380°C at 1004.1 to 1021.1 hPa and is not explosive and not oxidising on the basis of structural examination.
F-D3 has a predicted log Kow of 9 and predicted water solubility of 1.3E-06 mg/l at 20°C.
In contact with water, F-D3 reacts slowly (half-lives of >7.5 d at pH 5, 6 d at pH 7, 11 min at pH 9 and 25°C). The half-lives described are for the removal of parent substance by ring-opening. Complete reaction to the ultimate end products would take longer. 1,5-Dihydroxy-1,3,5-trimethyl-1,3,5-tris(3,3,3-trifluoropropyl)trisiloxane and 1,3-tris[(3,3,3-trifluoropropyl)methyl]disiloxane-1,3-diol are the postulated intermediate hydrolysis products, while 3,3,3-trifluoropropylmethysilanediol is the final hydrolysis product, according to the following series of reaction:
[-Si(CH3)(CH2CH2CF3)O-]3+ H2O → HOSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)OH
HOSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)OH + H2O → HOSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)(OH) + CH3Si(CH2CH2CF3)(OH)2
HOSi(CH2CH2CF3)(CH3)OSi(CH2CH2CF3)(CH3)(OH) + H2O → 2CH3Si(CH2CH2CF3)(OH)2
Silanediols may undergo condensation reactions to give siloxane dimers, oligomers and polymers, according to the scheme:
RR’Si(OH)2 |
RR’Si(OH)OSi(OH)RR’ |
RR’Si(OH)O[SiRR’(OH)O]nSi(OH)RR’ |
(where R is an alkyl or aryl side-chain)
The silanol hydrolysis product may undergo condensation reactions in solution to give siloxane dimers, and linear and cyclic oligomers. A dynamic equilibrium is established. The overall rate and extent of condensation is dependent on nominal loading, temperature, and pH of the system, as well as what else is present in the solution.
The condensation reactions of silanediols may be modelled as an equilibrium between monomer, dimer, trimer and tetramer, with the linear tetramer cyclising to the thermodynamically stable cyclic tetramer. The reactions are reversible unless the cyclic tetramer concentration exceeds its solubility; in this case, the cyclic tetramer forms a separate phase, driving the equilibrium towards the tetramer. At loadings above about 30 mg/l the concentration of the cyclic tetramer of the silanol hydrolysis product is predicted to exceed its solubility, resulting in formation of a separate phase. In addition, the cyclic tetramer is expected to have a high volatility from water and this may cause losses from water under some conditions. Further information is given in a supporting report (PFA 2013am) attached in Section 13.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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