Tetradecylamine

Short-term toxicity to aquatic invertebrates

Description of key information

Toxicity to Daphnia magna reported from a GLP guideline study on an analogous substance: 48h-EC50 = 0.09 mg/l (Noack, 1994)
Toxicity to Daphnia magna reported from secondary source: 48-EC50 = 0.013-0.019 mg/l (US EPA ECOTOX, 2014)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.09 mg/L

Additional information

For the determination of the short-term toxicity of Tetradecylamine to aquatic invertebrates, three data are reported: one from a GLP guideline study on an analogous substance (Noack, 1994), one from a secondary source on the substance itself (US EPA ECOTOX, 2014) and one from a (Q)SAR prediction (Kovarich, 2014).

The short-term toxicity of Amines, coco alkyl (CAS 61788-46-3) to Daphnia magna was determined to be 0.09 mg/l in a GLP-compliant study conducted in accordance with OECD Guideline 202 (Noack, 1994). The result of this study is considered reliable with restrictions (Klimisch 2) and is used, by analogy, as key value for the assessment of Tetradecylamine. This data is by the way consistent with a Klimisch 4 data collected from a secondary source (US EPA ECOTOX, 2014) which reports a 48h-EC50 on Daphnia magna in the range 0.013-0.019 mg/l.

Besides, the toxicity of Tetradecylamine was estimated on the basis of adequate (Q)SAR predictions from scientifically valid model: ACD/Aquatic toxicity and ECOSAR (Kovarich, 2014). Although those models fulfil the characterisation criteria specified in the OECD Guidance Document on the validation of (Q)SAR models, the prediction results were disregarded as they were assessed to be unreliable or of low reliability (Klimisch 3).