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Diss Factsheets

Ecotoxicological information

Toxicity to birds

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Administrative data

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Endpoint:
long-term toxicity to birds
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984-02-15 - 1984-03-05
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No bodyweights are reported.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 205 (Avian Dietary Toxicity Test)
Deviations:
yes
Remarks:
no bodyweights are reported
GLP compliance:
no
Dose method:
feed
Analytical monitoring:
no
Vehicle:
yes
Details on preparation and analysis of diet:
vehicle: sunflower oil
Test organisms (species):
Coturnix coturnix japonica
Details on test organisms:
Wild-coloured Japanese quails from the random breeding of the Ornithological Research Centre Seebach were used without sex differentiation at the age of 11 days.
Limit test:
no
Total exposure duration (if not single dose):
5 d
No. of animals per sex per dose and/or stage:
10 animals per dose
Control animals:
yes, plain diet
Nominal and measured doses / concentrations:
Nominal: 5000 mg/kg diet
Details on test conditions:
The test substance was mixed into the feed (turkey fattening feed) with the addition of 20 g sunflower oil per kg. The test substance was applied to the feed over a period of 5 days.
Reference substance (positive control):
no
Key result
Duration (if not single dose):
5 d
Dose descriptor:
LC50
Effect level:
> 5 000 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Further details on results:
The test animals showed delayed growth.The intake of the test food by the test animals was reduced.
Symptomatology: The treatment was tolerated without symptoms.
Lethality: No test animal died.
Validity criteria fulfilled:
yes
Conclusions:
The acute oral LD50 of 3-Methylpyrazol to japanese quails is > 5000 mg/kg diet.
Executive summary:

The acute oral LD50 of 3-Methylpyrazol to japanese quails is > 5000 mg/kg diet.

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not stated
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No body weights are reported in the test report.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 223 (Avian Acute Oral Toxicity Test)
Deviations:
yes
Remarks:
no body weights are reported
GLP compliance:
no
Dose method:
gavage
Analytical monitoring:
no
Vehicle:
yes
Details on preparation and analysis of diet:
vehicle: water
Test organisms (species):
Coturnix coturnix japonica
Details on test organisms:
Japanese quail female. Age 32 weeks, from random breeding at the Ornithological Research Centre Seebach. The average body mass at the start of the experiment was 121.7 ± 13.7 g.
Limit test:
no
Total exposure duration (if not single dose):
1 d
Post exposure observation period:
14 days
No. of animals per sex per dose and/or stage:
5 animals per dose
Control animals:
no
Nominal and measured doses / concentrations:
5 logarithmically graded dose groups of 5 animals each in the dose range from 385 to 1098 mg/kg body mass, progressor 1.3.
Details on test conditions:
The test substance dissolved in water was administered once in graduated concentrations in a volume of 1 ml liquid per 100 g body mass Japan quail. The application was carried out by means of a rigid gavage.
Reference substance (positive control):
no
Key result
Duration (if not single dose):
1 d
Dose descriptor:
LD50
Effect level:
515 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Mortality and sub-lethal effects:
Ruffled plumage, weakness, lateral recumbency, ataxia (turning movements, head turning), apathy, sometimes increased salivation, wing tremor. Exitus occurred after 2 hours to 5 days after application.
Validity criteria fulfilled:
yes
Conclusions:
The acute oral toxicity LD50 of 3-Methylpyrazol to Japanese quails is 515 mg/kg bodyweight.
Executive summary:

The acute oral toxicity of 3-Methylpyrazol to 32 weeks old Japanese quails was assessed over 14 days similar to OECD 205. Test material was administered as a single dose to the birds by gavage at 385-1098 mg ai/kg bw. The acute oral LD50was 515 mg ai/kg bw.

 

Description of key information

Short-term toxicity  to Coturnix cotirnix japonica

Key value for chemical safety assessment

Short-term EC50 or LC50 for birds:
5 000 mg/kg food

Additional information

5000 mg/kg food was the highest tested dose. Since no effects were observed, the LD50 does exceed this value by far, nevertheless the exposure assessment is performed using this figure as worst case scenario.