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EC number: 215-716-0 | CAS number: 1345-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation in vitro:
In this in vitro skin irritation test in the EPISKIN model with test item dibismuth trisulphide the results indicated that the test item is considered to be a non-irritant (NI) [UN GHS: No Category].
Eye irritation in vivo:
In conclusion, test item Dibismuth trisulfide (Bi2S3) applied to the rabbits' eye mucosa, caused slight conjunctival irritant effects, fully reversible
within 24 hours.
According to the EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified and has no obligatory labelling requirement for eye irritation.
According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
In an in vitro skin irritation test using the EPISKIN model, the test item dibismuth trisulfide did not show significantly reduced cell viability in comparison to the negative control. Test item viability results were above 50% when compared to the viability values obtained from the negative control.
Positive and negative controls showed the expected cell viability values within acceptable limits. The experiment was considered to be valid.
The results obtained from this in vitro skin irritation test, using the EPISKIN model, indicated that the test item Dibismuth trisulfide reveals no skin irritation potential under the utilised testing conditions. According to the current OECD Guideline No. 439, dibismuth trisulfide is considered a non-irritant to skin and is therefore not classified. No further in vivo test has to be performed.
Eye irritation in vitro
In an in vitro eye corrosives and severe irritants study, using the Isolated Chicken Eyes model with Dibismuth trisulfide, no ocular corrosion or
severe irritation potential was observed. Thus, according to the guideline OECD 438, Dibismuth trisulfide cannot be classified as an ocular
corrosive or severe eye irritant. Furthermore, the results suggest that the test item was slightly irritating. However, in relation to the irritation
potential, a further in vivo rabbit study is required for classification.
Eye irritation in vivo
According to OECD guideline 405 the eye irritation of dibismuth trisulfide was determined. In conclusion, test item dibismuth trisulfide applied to the rabbits' eye mucosa, caused slight conjunctival irritant effects, fully reversible within 24 hours.
According to the EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified and has no obligatory labelling requirement for eye irritation.
According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category.
Justification for selection of skin irritation / corrosion endpoint:
Most reliable study
Justification for selection of eye irritation endpoint:
Most reliable study
Justification for classification or non-classification
Based on skin irritation data available for dibismuth trisulfide no classification and labelling is required according to Regulation No (EC) 1272/2008 (CLP) or Directive 67/548/EEC (DSD) criteria.
According to the EC criteria for classification and labelling requirements for dangerous substances and preparations, the test item does not have to be classified as irritant to eyes and has no obligatory labelling requirement for eye irritation. According to Regulation (EC) No. 1272/2008, the test item has not been classified into any category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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