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EC number: 215-716-0 | CAS number: 1345-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A basic toxicokinetics assessment of dibismuth trisulfide was based on physicochemical and toxicological data and literature of dibismuth trisulfide, as well as on read across data from bismuth. From these data, absorption was assessed to be very low, and the oral route is considered as most appropriate route for testing systemic toxicity. Distribution, metabolism and elimination were also shortly discussed, but not elaborated much into detail based on the limited absorption.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 5
- Absorption rate - dermal (%):
- 5
- Absorption rate - inhalation (%):
- 1
Additional information
SUMMARY
Based on the physical form and low water solubility, but mainly on the absence of toxicity in acute and repeated dose oral toxicity studies, oral absorption of dibismuth trisulfide is assumed to be very low. This conclusion is confirmed by the literature on oral absorption of insoluble bismuth compounds.
The physical state, the molecular weight, the water solubility, the vapour pressure, but mainly the absence of toxicity in acute dermal animal testing and the absence of irritating or corrosive and sensitizing potential the dermal absorption of dibismuth trisulfide is assumed to be very low.
The low vapour pressure and the tendency of dibismuth trisulfide particles to agglomerate and deposit do not favour the respiratory uptake, whereas the particle size and the low water solubility favour the assumption that particle can be absorbed on different stages of the stages of the respiratory tract and via the gastrointestinal tract. However,the absence of toxicity in acute inhalation toxicity and acute and repeated dose oral toxicity studies, the respiratory and oral absorption of dibismuth trisulfide is assumed to be very low.
Based on the low water solubility, but mainly based on the absence of target organs or signs of toxicity in a repeated dose toxicity study with the Read-Across substance bismuth in rats up to the limit concentration, distribution was considered minimal. Data from literature indicates accumulation in the kidney, however this is not considered to be relevant since the absorption of poorly water-soluble inorganic bismuth compounds is considered to be low.
There is no direct indication of bioaccumulation potential of dibismuth trisulfide in lung, adipose tissue, bone or stratum corneum. However, literature describes that bismuth compounds may accumulate in the kidney. Taking into account that absorption of dibismuth trisulfide is considered to be very low, accumulation is not considered to be relevant.
Since the oral absorption of dibismuth trisulfide is very low, therefore the estimated favoured excretion route is the faecal route. However, very small quantities of absorbed and therefore dissolved parts are excreted via urine.
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