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EC number: 211-708-6 | CAS number: 688-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Animal data
The sensitizing potential of 2-ethylhexyl methacrylate was evaluated in three independent studies performed by intradermal injection and topical applications on guinea pigs according to a modified Magnusson and Kligman method.
In the's study (1981), the induction phase has been realized both by intradermal route on day 1 (5 % in paraffin) and by cutaneous route on day 6 -7 (undiluted) in 2 groups of guinea pigs: 5 females for control group and 10 females for treated group. The challenge phase was realized on day 21 by cutaneous application of 3 % on petrolatum on the flank; the cutaneous reactions were scored 48 and 72 hours after the challenge phase. Either mild or well-defined erythema was observed in three of 10 animals 48 hours following challenge applications. This effect was accompanied by slight oedema in two animals at 72 hours. This represents a 30% sensitization rate; therefore, the product is considered to be a Moderate Contact Allergen according to the Maximization grading system.
In another guideline GPMT study where 2-EHMA (Allen, 1999) was tested at an intradermal induction concentration of 1 % in water (w/v) and an epicutaneus induction concentration of 100 %, 0/20 animals reacted when challenged with 75 % or undiluted 2 -EHMA after 24 or 48 h after the challenge application. 2 -EHMA was non-sensitising in this test.
In the Clemmensen study (1984), the induction phase has been realized both by intradermal route on day 1 (5 or 25 %) and by cutaneous route on day 7 -8 (undiluted) in 2 groups of 20 or 12 female guinea pigs, respectively. The challenge phase was realized on day 21 by cutaneous application of 3 or 25% solution; the cutaneous reactions were scored 48 and 72 hours after the challenge phase. No positive skin reaction was observed in the 20 animals challenged with 3% and positive skin reaction was observed in two of 12 animals challenged with 25%. This represents a 16% sensitization rate; therefore, the product is considered to be a Mild Contact Allergen according to the Maximization grading system.
In a fully valid LLNA according to OECD 429, treatment with 2-EHMA caused Stimulation Indices (S.I.) of 1.53, 2.66, and 2.85 at concentrations of 25, 50, and 100% in acetone:olive oil (4+1). A clear dose response was observed, however the treshold of 3 was not reached indicating no skin sensitizing potential of the test item in this test system relevant for classification.Human data
There are very limited patch test data on 2-EHMA which do not allow drawing a conclusion regarding prevalence or potency. By analogy to the other lower alkyl methacrylates it is expected that 2 -EHMA is a skin sensitiser of low potency in humans.
Short description of key information:
2-ethylhexyl methacrylate was a mild to moderate skin sensitizer in guinea pig maximization tests.2-ethylhexyl methacrylate is not considered as skin sensitizer in a fully valid LLNA.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Inhalation exposure is not considered as a relevant pathway of exposure for 2-EHMA. Therefore, respiratory sensitisation has not to be addressed.
Short description of key information:
Inhalation exposure is not considered as a relevant pathway of exposure for 2-EHMA. Therefore, respiratory sensitisation has not to be addressed.
Justification for classification or non-classification
According to the available data and CLP criteria, 2-ethylhexyl methacrylate is considered as a skin sensitiser of low potency and has therefore to be classified with R43/ skin sensitiser under 67/548/EEC and as a Cat. 1 skin sensitiser according to CLP (1272/2008/EC) and as Cat 1B, skin sensitiser according to UN GHS (2009) requirements.
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