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Diss Factsheets
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EC number: 211-661-1 | CAS number: 682-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No specific studies are available however based on the physicochemical data, toxicity data and theoretical assessment, the basic toxicokinetics of trimethylolpropane diallyl ether can be adequately characterised. Trimethylolpropane diallyl ether is likely to be rapidly and extensively absorbed following oral or inhalation exposure; absorption following dermal exposure is likley to be less extensive and more gradual. Rapid and extensive distribution is predicted. Extensive hepatic metabolism of Trimethylolpropane diallyl ether is predicted, indicating that excretion is rapid bioaccumulation is unlikely.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No data are available, however an adequate assessment of the basic toxicokinetics of trimethylolpropane diallyl ether can be made from the exisiting chemistry and toxicity data and theoretical considerations, wtithout the need for specific testing.
Absorption
Extensive oral absorption of trimethylolpropane diallyl ether is predicted based on its molecular size, solubility, chemical structure and on the basis of experience with other related compounds. The trimethylolpropane diallyl ether molecule satisifies Lipinski's rule of 5 (OECD QSAR Toolbox) and is therefore considered likely to be bioavailable. Oral absorption is demonstrated by the findings of the acute oral toxicity study and systemic effects in the 30-day oral study. Absorption following inhalation exposure is also likely to be extensive. Dermal absorption is likely to be less extensive, but is likely to occur to some extent. The results of the acute dermal toxicity study support this theory.
Distribution
No data are available, however rapid and extensive distribition can be predicted based on the knowledge of other alcohols. Effects in the 30 -day study indicate distribution to the liver. The extensive hepatic metabolism predicted for trimethylolpropane diallyl ether
indicates that bioaccumulation is unlikely.
Metabolism
The OECD QSAR Toolbox (liver metabolism simulator) predicts a total of 32 liver metabolites of trimethylolpropane diallyl ether, no skin metabolites and one gastro-intestinal tract metabolite based on documented metabolic reactions seen with compounds containing similar functional groups. The extensive hepatic metabolism predicted for trimethylolpropane diallyl ether is consistent with the effects on the liver and additionally indicates that bioaccumulation is unlikely.
Excretion
Rapid and extensive renal and/or hepatic excretion of trimethylolpropane diallyl ether and its metabolites is likely, with no potential for bioacumulation based on chemical properties and also on the relatively low toxicity seen in the 30 -day study. The effects on the liver in the 30 -day study indicate that biliary excretion of the metabolites of trimethylolpropane diallyl ether is likely.
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