Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-868-4 | CAS number: 624-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral route
In an acute oral toxicity study (similar to OECD testing guideline 401 and according to GLP) (Douds, 1994a), groups of fasted, young adults Sprague-Dawley rats (5/sex) were given a single oral dose of undiluted methyl ethyl sulphide by gavage at dose of 5000 mg/kg bw (limit test) and observed for 14 days. One male rat died on day 1. All other animals survived up to the end of the study. Clinical signs were observed in all animals: salivation, piloerection, wobbly gait, decreased activity, lacrimation, eyelids partially closed, transient incidences of urine stain, transient incidences of rales, rough haircoat, decreased/no defecation, dark material around the facial area, low food consumption. Gross internal findings noted at necropsy for the animal that died included clear yellow-red fluid contents in the urinary bladder, light green staining of glandular mucosa in the stomach and greenish-red mucoid contents in the entire tract of the small intestine. No gross internal findings were observed at necropsy on study day 14 for the surviving animals. The Oral LD50(combined males/females) was > 5000 mg/kg bw.
Dermal route
The single-dose dermal toxicity of methyl ethyl sulphide was evaluated in Sprague-Dawley rats (similar to OECD test guideline 402 and according to GLP) (Douds, 1994b). A limit test was performed in which one group of 5 male and 5 female rats received a single dermal administration of the test article at the dose of 2000 mg/kg bw. Following dosing, the limit test rats were observed daily and weighed weekly. A gross necropsy examination was performed on all limit test animals at the time of scheduled euthanasia (day 14). No mortality occurred during the limit test. The most notable clinical abnormalities observed during the study included dark material around the facial area, urine stain and dermal irritation at the site of the test application. Body weight gain was noted for the majority of animals during the test period. No significant gross internal findings were observed at necropsy on day 14. The acute dermal LD0 of methyl ethyl sulphide was estimated to be greater than 2000 mg/kg bw in the rat.
Inhalation route
In an acute inhalation toxicity study performed according to the OECD guideline # 403 and GLP, no mortality and clinical sign of toxicity was observed in male and female rats exposed to an atmosphere concentration of 21.72 mg/l (6988 ppm) of methyl ethyl sulphide for 4 hours. At necropsy, dark areas were observed on lungs of 1 female rat (Colin and Jackson, 1988).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 15-NOV-1993 to 11-APR-1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to a recognised guideline and GLP
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- limit test at 5000 mg/kg bw
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc., Portage, Michigan
- Age at study initiation: young adults
- Weight at study initiation: from 248 to 288 g for males and from 253 to 264 g for females (on day -1)
- Fasting period before study: yes (overnight)
- Housing: individually in stainless steel cages
- Diet: Purina certified Rodent chow #5002 ad libitum
- Water (e.g. ad libitum): municipal tap water treated by reverse osmosis or deionization, ad libitum
- Acclimation period: for a minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 62 to 72 °F (# 16.7 to 22.2°C)
- Humidity: 40 to 58%
- Air changes: 10 to 12 air changes per hour
- Photoperiod: 12 hrs dark / 12 rs light
IN-LIFE DATES: From 15-DEC-1993 to 29-DEC-1993 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 6 mL/kg
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical signs: 2 times on study day 0, and daily thereafter
> body weight: prior to fasting (day -1), prior to dosing on day 0, for all surviving animals on day 7 and 14, or at the time for death
- Necropsy of survivors performed: yes - Statistics:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- One male rat died on day 1. All other animals survived up to the end of the study
- Clinical signs:
- other: The most notable clinical abnormalities observed during the study included salivation which was noted in 8/10 animals on study day 0 only, piloerection noted in 8/10 animals during the study day 0 to 2 interval, wobbly gait noted in all test animals on st
- Gross pathology:
- Gross internal findings noted at necropsy for the animal that died included clear yellow-red fluid contents in the urinary bladder, light green staining of glandular mucosa in the stomach and greenish-red mucoid contents in the entire tract of the small intestine. No gross internal findings were observed at necropsy on study day 14 for the surviving animals.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and GHS
- Conclusions:
- The acute oral LD50 of Methyl Ethyl Sulfide was estimated to be greater than 5000 mg/kg in the rat.
- Executive summary:
In an acute oral toxicity study (similar to OECD testing guideline 401 and according to GLP), groups of fasted, young adults Sprague-Dawley rats (5/sex) were given a single oral dose of undiluted methyl ethyl sulfide by gavage at dose of 5000 mg/kg bw (limit test) and observed for 14 days. One male rat died on day 1. All other animals survived up to the end of the study. Clinical signs were observed in all animals: salivation, piloerection, wobbly gait, decreased activity, lacrimation, eyelids partially closed, transient incidences of urine stain, transient incidences of rales, rough haircoat, decreased/no defecation, dark material around the facial area, low food consumption. Gross internal findings noted at necropsy for the animal that died included clear yellow-red fluid contents in the urinary bladder, light green staining of glandular mucosa in the stomach and greenish-red mucoid contents in the entire tract of the small intestine. No gross internal findings were observed at necropsy on study day 14 for the surviving animals. The Oral LD50(combined males/females) was > 5000 mg/kg bw.
Reference
Table 1: Number of animals dead and with evident toxicity and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (day) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
5000 |
1/5 |
0/5 |
1/10 |
Day 1 |
5/5 |
5/5 |
10/10 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- GLP guideline study
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Albino rats, Spraque-Dawley. One control group and 1 test group each of 5 male and 5 female rats.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- By inhalation of a test atmosphere containing vapour of the test substance.
4 hours continuous whole-body exposure. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas cromatography
- Duration of exposure:
- 4 h
- Concentrations:
- 21.72 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- 14 days post exposure
- Statistics:
- Not appropriate
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 21.72 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study
- Clinical signs:
- other: (a) During exposure: No abnormalities. (b) During the observation period: No abnormalities
- Body weight:
- Slight loss of bodyweight or reduction of rate of bodyweight gain for one day following exposure.
- Gross pathology:
- Macroscopic pathology: Dark areas on lungs of 1 female rat exposed to METHYL ETHYL SULFIDE.
- Other findings:
- Food and water consumption: Food consumption was slightly reduced for 1 day following exposure. Possible slight elevation of water consumption for a few days following exposure in female rats only.
Lung weight to body weight ratio: The lung weight to body weight ratio for female rats exposed to METHYL ETHYL SULFIDE was higher than the control values. Males were unaffected. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and GHS
- Conclusions:
- The 4h-LC0 in higher than 21.72 mg/l in both male and female rats
- Executive summary:
In an acute inhalation toxicity study performed according to the OECD guideline # 403 and GLP, no mortality and clinical sign of toxicity was observed in male and female rats exposed to an atmosphere concentration of 21.72 mg/l (6988 ppm) of methyl ethyl sulfide for 4 hours. At necropsy, dark areas was observed on lungs of 1 female rat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 21 720 mg/m³ air
- Quality of whole database:
- GLP guideline study
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 15-NOV-1993 to 03-MAR-1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study similar to OECD testing guideline and according to GLP
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- occlusive dressing, test temperature
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Inc., Portage, Michigan
- Age at study initiation: young adults
- Weight at study initiation: 201 to 213g for males and 238 to 285 for females (on day 0 of study)
- Fasting period before study: data not available
- Housing: individually in suspended stainless steel cages
- Diet: Purina Certified Rodent chow #5002, ad libitum
- Water: municipal tap water treated by reverse osmosis or deionization, ad libitum
- Acclimation period: for a minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 62 to 71°F (# 16.7 to 21.7°C)
- Humidity: 37 to 57%
- Air changes: 10 to 12 changes per hour
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From 22-DEC-1993 to 05-JAN-1994 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal trunk area
- % coverage: 10%
- Type of wrap if used: 4 ply porous gauze dressing backed with plastic wrap (occlusive binding)
REMOVAL OF TEST SUBSTANCE
- Washing: residual test material was removed using gauze moistened with distilled water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied: 2000 mg/kg bw
- Concentration: undiluted - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw (limit test)
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical signs: 2 times on study day 0 (postdose) and daily thereafter (day 1-14)
> mortality: twice daily, in the morning and afternoon
> dermal observations: animals were observed for erythema and edema following patch removal on day 1 and daily thereafter
> body weight: prior to dosing on day 0 and on days 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- not applicable
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no mortality
- Mortality:
- No mortality occurred during the limit test.
- Clinical signs:
- other: The most notable clinical abnormalities observed during the study included dark material around the facial area, urine stain and dermal irritation at the site of test article application.
- Gross pathology:
- No significant gross internal findings were observed at necropsy on study day 14.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and GHS
- Conclusions:
- The acute dermal LD0 of Methyl Ethyl Sulfide was estimated to be greater than 2000 mg/kg in the rat. No mortality was observed.
- Executive summary:
The single-dose dermal toxicity of methyl ethyl sulfide was evaluated in Sprague-Dawley rats (similar to OECD test guideline 402 and according to GLP). A limit test was performed in which one group of 5 male and 5 female rats received a single dermal administration of the test article at the dose of 2000 mg/kg bw. Following dosing, the limit test rats were observed daily and weighed weekly. A gross necropsy examination was performed on all limit test animals at the time of scheduled euthanasia (day 14).
No mortality occurred during the limit test. The most notable clinical abnormalities observed during the study included dark material around the facial area, urine stain and dermal irritation at the site of the test application. Body weight gain was noted for the majority of animals during the test period. No significant gross internal findings were observed at necropsy on day 14.
The acute dermal LD0 of methyl ethyl sulfide was estimated to be greater than 2000 mg/kg bw in the rat.
Reference
Table 1: Number of animals dead and with evident toxicity and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
2000 |
0/5 |
0/5 |
0/10 |
- |
5/5 |
5/5 |
10/10 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- GLP guideline study
Additional information
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 and the available acute toxicity data, ethylmethyl sulphide don't warrant a classification for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.