Methyl crotonate

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE

EPISUITE 4.11

2. MODEL (incl. version number)

ECOSAR 1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL

CAS-Nr.: 623-43-8
Smiles: O=C(OC)C=CC

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
[[Explain how the model fulfils the OECD principles for (Q)SAR model validation. Consider attaching the QMRF and/or QPRF or providing a link]

See: METHODOLOGY DOCUMENT for the ECOlogical Structure-Activity Relationship Model (ECOSAR) Class Program

5. APPLICABILITY DOMAIN
[Explain how the substance falls within the applicability domain of the model]

Acrylates/Fumerate/Maleates as well as vinyl/allyl esters are included in the model training set.


6. ADEQUACY OF THE RESULT
[Explain how the prediction fits the purpose of classification and labelling and/or risk assessment]

Because the substance is registered as Intermediate according to Art. 18 REACH, no study is required for this endpoint. For RMM the QSAR data are sufficient.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2022

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

42.5 mg/L

Conc. based on:

test mat.