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EC number: 210-511-2 | CAS number: 617-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral LD50 of ethyl pyruvate in a vehicle of corn oil is greater than 5000 mg/kg in male and female Sprague-Dawley rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 1989 - 21 November 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: This study was conducted in compliance with the Food and Drug Administration (FDA) Good Laboratory Practice (GLP) standards, as set forth in 21 CFR Part 58.
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Simonsen Laboratories (Gilroy, CA)
- Females (if applicable) nulliparous and non-pregnant: -Not specified
- Age at study initiation: 26 days of age on receipt.
- Weight at study initiation:Male rats weighing in at 106 and 118 g and five female rats weighing between 93 and 109 g
- Fasting period before study:
- Housing:Rats were housed five per cage in hanging polycarbonate cages containing hardwood-chip bedding (Sani-Chips®, P.J. Murphy Forest Products, Montville, NJ
- Diet (e.g. ad libitum): A commercial rodent diet (Purina Certified Rodent Chow, #5002) and UV-purified drinking water, available via an automatic watering system, were supplied ad libitum.
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): oom temperature during the study was maintained at 75 ± 3°F
- Humidity (%): relative humidity of 24% to 49%
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): Not specified
IN-LIFE DATES: From: 31 October 1989 To: 21 November 1989 - Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- To determine a range of acute oral toxicity of ethyl pyruvate (with a limit of 5000 mg/kg), we treated groups of five male rats weighing between 106 and 118 g and five female rats weighing between 93 and 109 g with 1250, 2500, or 5000 mg/kg of ethyl pyruvate in a vehicle of corn oil.
Dose mixtures were administered in a single dose by oral gavage, using a calibrated syringe and ball-tipped intubation needle, at a volume of 1 ml per 100 g of body weight (10 ml/kg); dose volumes were based on body weights taken immediately before dosing. All rats were fasted overnight before treatment.
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg dose volumes were based on body weights taken immediately before dosing.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 1250, 2500, or 5000 mg/kg of ethyl pyruvate in a vehicle of corn oil.
Dose mixtures were administered in a single dose by oral gavage. - No. of animals per sex per dose:
- 10 animals per dose.
5 females and 5 males. - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?)
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes/no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: - Statistics:
- No statistics provided
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred in any of the male or female rats treated with a single oral dose of ethyl pyruvate in a vehicle of corn oil at levels of 1250, 2500, or 5000 mg/kg
- Clinical signs:
- other: All male and female rats receiving 5000 mg/kg of the test substance were observed with tremors and gasping within 5 min of treatment. The tremors subsided within 10 min of treatment; all rats were hypoactive at that time and only two of the five female ra
- Gross pathology:
- No grossly observable abnormalities were apparent at the end of the 2-week observation period upon necropsy of male and female rats treated with 1250, 2500, or 5000 mg/kg methyl pyruvate.
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on the results of this study, we conclude that the acute oral LD50 of ethyl pyruvate in a vehicle of corn oil is greater than 5000 mg/kg in male and female Sprague-Dawley rats.
- Executive summary:
To determine the acute oral toxicity of ethyl pyruvate, SRI treated groups of young adult Sprague-Dawley rats containing five males and five females each with a single oral dose of ethyl pyruvate in a vehicle of corn oil at levels of 1250, 2500, or 5000 mg/kg. Daily observations for physiologic and behavioral responses and mortality were continued for 14 days after treatment. Body weights were taken shortly before administration of the test substance and weekly thereafter during the 2-week observation period. All rats were necropsied at the end of the 2-week study.
No deaths occurred in any of the male or female rats treated with a single oral dose of ethyl pyruvate in a vehicle of corn oil at levels of 1250, 2500, or 5000 mg/kg. All male and female rats receiving 5000 mg/kg of the test substance were observed with tremors and gasping within 5 min of treatment. The tremors subsided within 10 min of treatment; all rats were hypoactive at that time and only two of the five female rats continued to gasp. All 5000-mg/kg male and female rats appeared normal within 2 hr of treatment. No clinical signs of toxicity were observed in male and female rats following treatment with 1250 or 2500 mg/kg of the test substance.
Average weight gains of male and female rats treated with 5000 mg/kg ethyl pyruvate were only slightly lower than those of the 1250-mg/kg male and female rats. Average weight gains of male and female rats treated with 1250 and 2500 mg/kg ethyl pyruvate were comparable by sex. No grossly observable abnormalities were apparent in any of the male or female rats upon necropsy at the end of the 2-week study.
Based on the results of this study, we conclude that the acute oral LD50 of ethyl pyruvate in a vehicle of corn oil is greater than 5000 mg/kg in male and female Sprague-Dawley rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the CLP criteria LD50 values greater than 2000mg are not classified as hazardous and the acute oral LD50 of ethyl pyruvate in a vehicle of corn oil is greater than 5000 mg/kg in male and female Sprague-Dawley rats therefore we can confirm that the Ethyl Pyruvate is not classified as hazardous for the oral route.
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