Registration Dossier
Registration Dossier
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EC number: 207-622-3 | CAS number: 485-71-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
According to the study report the degradation of cinchonidine hydrochloride was 81.2% within 28 days (after acidification). Cinchonidine hydrochloride reached the criterion for ready biodegradability. In conclusion, cinchonidine can be considered as readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The read-across substance cinchonidine hydrochloride was tested in a CO2 Evolution Test according to the OECD Guideline 301 B for 28 days (and 29 days after acidification) to determine whether the test substance is readily biodegradable. On day 28 (after acidification) the degradation in the test vessels reached an extent of 81.2% (mean value of three replicates). There was a high variation in the degradation behaviour due to the difference in the lag phases in the replicate vessels with cinchonidine hydrochloride. Because of the differing lag phases the 10-d-window was evaluated separately. In vessel 15 the lag phase ended between day 4 and 7, in vessel 16 the lag phase ended between day 11 and 14 while in vessel 17 the lag ended between day 11 and day 14. The 10-d-window was reached in all three test vessels. In vessel 15 the degradation extent was already on day 11 above 60%. In vessel 16 and 17 the degradation extent on day 11 was still below 10% and on day 21 it was above 60%.Therefore, cinchonidine hydrochloride reached the pass level for ready biodegradability (60% ThCO2 within a 10-d window). In conclusion, cinchonidine can be considered as readily biodegradable.
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