Registration Dossier
Registration Dossier
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EC number: 207-101-0 | CAS number: 434-22-0
Endpoint summary
Administrative data
Description of key information
No acute toxicity studies with nandrolone are available. However, results of two subcutaneous acute toxicity studies are cited in RTECS database (Jan 2010):
Subcutaneous (rat): TDLO = 1.2 mg/kg bw; exposure time 3 days
[Acta Endrocrinologica (Copenhagen). (Periodica, Skolegade 12 E; DK-250 Valby Denmark) V.1-1948- v.47, p. 444, 1964 (ACENA7)]
Subcutanous (rabbit): TDLO = 2 mg/kg bw; exposure time 5 days
[Anatomical Record. (alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-1906/08- v. 142, p. 469, 1962 (ANREAK)]]
Key value for chemical safety assessment
Additional information
Ther are no acute toxicity studies with nandrolone available. However, results of two subcutaneous acute toxicity studies are cited in RTECS database (Jan 2010):
Subcutaneous application of nandrolone to female rats 3 days premating results in not further specified effects on fertility; TDLo: 1200 ug/kg (3D pre) [Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- v. 47, p. 444, 1964 (ACENA7)]
Daily subcutaneous application to female rabbits 5 days prior to mating leads to maternal effect in uterus, cervix and vagina; TDLo: 2 mg/kg (5D pre) [Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- v. 142, p. 469, 1962 (ANREAK)]
Justification for classification or non-classification
There are no oral, dermal or inhalation acute toxicity studies available. No classification is required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
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