Registration Dossier
Registration Dossier
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EC number: 205-755-1 | CAS number: 150-25-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 23 January 2017 to 16 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
- Remarks:
- validated analytical method used for quantification of the water samples
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- N,N-bis(2-hydroxyethyl)glycine
- EC Number:
- 205-755-1
- EC Name:
- N,N-bis(2-hydroxyethyl)glycine
- Cas Number:
- 150-25-4
- Molecular formula:
- C6H13NO4
- IUPAC Name:
- N,N-bis(2-hydroxyethyl)glycine
- Reference substance name:
- N-(2-hydroxyethyl)ethylenediaminetriacetic acid
- EC Number:
- 205-759-3
- EC Name:
- N-(2-hydroxyethyl)ethylenediaminetriacetic acid
- Cas Number:
- 150-39-0
- Molecular formula:
- C10H18N2O7
- IUPAC Name:
- N-{2-[bis(carboxymethyl)amino]ethyl}-N-(2-hydroxyethyl)glycine
- Reference substance name:
- Not specified
- IUPAC Name:
- Not specified
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Dihydrogen oxide
- Test material form:
- solid: crystalline
- Details on test material:
- Appearance: white crystalline powder
Storage conditions: at room temperature protected from light
Constituent 1
impurity 1
impurity 2
impurity 3
Results and discussion
Water solubility
- Key result
- Water solubility:
- 347 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 5.2
- Details on results:
- -Concentration analysed after 24, 48 and 72 hours of stirring: 366 g/L, 318 g/L and 356 g/L, resp.
-The mean of the three concentrations was reported as the water solubility of the substance.
-Maximum difference meets the criterion of = 15% (i.e. 14%)
No test substance was detected in the pretreated sample from the blank.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 347 g/L.
- Executive summary:
The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-MS. The pH of the aqueous samples was 5.2. From the measurements obtained after 24, 48 and 72 hours of stirring, the water solubility at 20°C was determined to be 347 g/L.
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