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EC number: 201-615-9 | CAS number: 85-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- Under the study conditions, the vapor pressure of the test substance was calculated (mean of three determinations) to be 2.23-E06 Pa at 20 °C.
- Executive summary:
A study was conducted to determine the vapour pressure according to OECD 104 resp. EU A.4 Method, in compliance with GLP. The vapor pressure of the test substance at 20 °C (PT, 20) was evaluated using the isothermal thermogravimetric effusion method. According to the guideline this method was validated in the range 10+E10 to 1 Pa using a set of reference substances with known vapor pressures. Based on the results from the pre-test the main test with three replicates was done between 130 °C and 180 °C. The test substance was added to the glass plate. The plate was placed in the TGA instrument. The weight loss of the test item was measured continuously as a function of time at different temperatures at constant nitrogen flow. Measurement program was: start at minimum temperature of 130 °C following with temperature increase: 10 °C with a ramp of 10 °C/min, Isothermal interval of 5 min and end temperature: 180 °C. A value of the vapour pressure of the test substance was determined using weight loss data obtained between 140 °C and 170 °C. Under the study conditions, the vapor pressure of the test substance was calculated (mean of three determinations) to be 2.23-E06 Pa at 20 °C (Wagner Rivas, 2017).
Reference
The evaporation rate of the test substance (VT) was calculated from the weight loss of the test substance at defined temperatures in a constant stream of nitrogen over periods of time. Linear regression analysis of log VT versus 1/T (1000/T) was performed for the test substance and for each reference substance. The evaporation rates at 20 °C (VT, 20) were determined from these relationships. The relationship between the values of VT, 20 of the reference substances and their known vapor pressures was established as a regression equation. The relationship between evaporation rate and vapor pressure, derived for 20 °C, includes the characteristics of the experimental setup, which are subsequently employed in the calculation of vapor pressure values at other temperatures.
Equation for the regression line of log PT as a function of log VT used for calibration:
log PT = 4.8560+1.1723 x log VT
The coefficient of correlation (R2) was 0.9977.
Equation for the temperature dependence of the vapor pressure of the test substance:
log PT=C+D x (a / T+b)=C+(D x b)+(D x a) / T
Description of key information
Determination of the vapour pressure according to OECD Guideline 104 and EU Method A.4 (Wagner Rivas, 2017).
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.