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Diss Factsheets
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EC number: 200-306-6 | CAS number: 57-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Explosiveness
Administrative data
Link to relevant study record(s)
- Endpoint:
- explosiveness, other
- Remarks:
- explosiveness of solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-02-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: SOP SPZ-420
- Principles of method if other than guideline:
- With the differential scanning calorimetry the heat flow between the (filled) sample crucible and a reference crucible (filled with an inert material or left empty) is measured as a function of the oven temperature and of time.
- GLP compliance:
- not specified
- Key result
- Parameter:
- other: Explosiveness (not specified)
- Remarks on result:
- negative (not further specified)
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Creatine (anhydrous) is not considered to be an explosive.
- Executive summary:
The substance Creatine (anhydrous) was tested to check for assignment to the physical hazard classes “self-reactive substances” to get information on the potential explosive properies of the substance. The result of the DSC test (temperature range 30 °C – 500 °C) showed an endothermic reaction starting at about 220 °C. The enthalpy was 514.4 J/g.
According the "Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance" testing should be carried out if the screening procedure identifies the material as having the potential to possess explosive properties, or there is any doubt. As the result of the DSC did only show an endotheric reaction at about 220°C the sample can be excluded from the hazard class “self-reactive substances” and testing on explosiveness does not need to be conducted.
The result of the differential scanning calorimetry described indicates that the substance is not explosive as there is no exothermic decomposition energy more than 500 J/g and hence no onset of exothermic decomposition below 500ºC.
Therefore, Creatine (anhydrous) is not considered to be an explosive.
Reference
The result of the DSC test (temperature range 30 °C – 500 °C) showed an endothermic reaction starting at about 220 °C. The enthalpy was 514.4 J/g.
According the "Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance" testing should be carried out if the screening procedure identifies the material as having the potential to possess explosive properties, or there is any doubt. As the result of the DSC did only show an endotheric reaction at about 220°C the sample can be excluded from the hazard class “self-reactive substances” and testing does not need to be conducted.
Description of key information
The result of the differential scanning calorimetry conducted indicates that Creatine (anhydrous) is not an explosive
as there is no exothermic decomposition energy more than 500 J/g and hence there is no onset of exothermic decomposition below 500ºC.
Key value for chemical safety assessment
- Explosiveness:
- non explosive
Additional information
A differential scanning calorimetry with Creatine (anhydrous) was conducted to get information on the potential explosive properies of the substance. The result of the DSC test (temperature range 30 °C – 500 °C) showed an endothermic reaction starting at about 220 °C. The enthalpy was 514.4 J/g. Therefore, Creatine (anhydrous) is not considered to be an explosive.
Justification for classification or non-classification
According the results of the differential scanning calorimetry Creatine (anhydrous) is considered to be not an explosive and does not have to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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