Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
204-002-4
CAS no.:
112-75-4
Index number:
Molecular formula:
C16H35N
SMILES:
CCCCCCCCCCCCCCN(C)C
InChI:
InChI=1S/C16H35N/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17(2)3/h4-16H2,1-3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
18
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance causes severe skin burns and eye damage, is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects and is harmful if swallowed.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye damage.

Breakdown of all 580 C&L notifications submitted to ECHA

Acute Tox. 4 H302
Aquatic Acute 1 H400
Skin Corr. 1B H314
Aquatic Chronic 1 H410
Eye Dam. 1 H318
Skin Corr. 1C H314
Aquatic Chronic 2 H411
Not Classified
Eye Irrit. 2 H319
Skin Irrit. 2 H315
STOT SE 3 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 13 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: lubricants and greases, heat transfer fluids, hydraulic fluids and metal working fluids.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals at dedicated facilities, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, lubrication at high energy conditions and in partly open process, greasing at high energy conditions and heat / pressure transfer fluids in closed systems.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: metal working fluids, hydraulic fluids, lubricants and greases and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, laboratory work, transfer of substance into small containers and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: lubricants and greases, metal working fluids, heat transfer fluids, hydraulic fluids and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals at dedicated facilities, closed processes with no likelihood of exposure, transfer of substance into small containers, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; do not eat, drink or smoke when using this product; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. Immediately call a poison center or doctor/physician. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ALBEMARLE EUROPE SPRL, Parc Scientifique (Einstein) Rue du Bosquet 9 1348 LOUVAIN-LA-NEUVE Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Clariant Produkte (Deutschland) GmbH, August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany
  • CU Chemie Uetikon GmbH, Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany
  • Global Amines Germany GmbH, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • Global Amines Germany GmbH - CNW1, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (4), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals GmbH, Kupferstrasse 1 46446 Emmerich Northrhine-Westfalia Germany
  • PCAS, 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France
  • RHODIA OPERATIONS - 44, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France
  • Taminco BV, Pantserschipstraat 207 9000 Gent Belgium
  • Procter & Gamble Manufacturing Belgium N.V., Temselaan 100 1853 Strombeek-Bever Belgium
  • Procter & Gamble Technical Centres Limited, The Heights, Brooklands KT13 OXP Weybridge, Surrey United Kingdom

Substance names and other identifiers

Dimethyl myristamine
Other
Dimethyl(tetradecyl)amine
EC Inventory
dimethyl(tetradecyl)amine
REACH pre-registration
1-Tetradecanamine, N,N-dimethyl-
C&L Inventory
Dimethyl(tetradecyl)amine
C&L Inventory, Registration dossier, Other
Dimethyl(tetradecyl)amine
C&L Inventory, Registration dossier, Other
Dimethylmyristylamin
C&L Inventory
FDM40
Registration dossier
N,N-dimethyltetradecan-1-amine
C&L Inventory, Registration dossier, Other
N,N-dimethyltetradecan-1-amine
C&L Inventory, Registration dossier
N,N-Dimethyltetradecylamine
C&L Inventory, Registration dossier
N,N-Dimethyltetradecylamine
Registration dossier
Tetradecyldimethylamine
Registration dossier
ADMA (R) 14 Amine
Registration dossier
AT-1214
Registration dossier
AT-1214A
Registration dossier
AT-1218A
Registration dossier
AT-1218AF
Registration dossier
AT-1218AM
Registration dossier
AT-1218AN
Registration dossier
AT-1263A
Registration dossier
AT-1265A
Registration dossier
AT-1270 LFFA
Registration dossier
AT-1270A
Registration dossier
AT-1270AE
Registration dossier
AT-1270AF
Registration dossier
AT-1450A
Registration dossier
AT-1495A
Registration dossier
Dimla C14
Registration dossier
Vegarol 1498 TAM
Registration dossier
112-75-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Other (100%) [2]
C Odour
Other (100%) [2]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 4 studies submitted
  • 4 studies processed
R Melting / freezing point
-33 - -11 °C @ 101.3 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 6 studies submitted
  • 4 studies processed
R Boiling point
237 - 300 °C @ 100.1 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 6 studies submitted
  • 4 studies processed
R Density
0.778 - 0.801 g/cm³ @ 20 °C [4]
R Relative density
0.778 - 0.802 @ 4 - 20 °C [6]

Type of Study provided
Studies with data
Key study 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Study results
  • 6 studies submitted
  • 5 studies processed
R Vapour pressure
0.02 - 9.4 Pa @ 20 - 50 °C [9]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 13 studies submitted
  • 12 studies processed
R Pow
18.28 - 115 143 @ 20 °C and pH 7.1 - 8.8 [10]
R Log Pow
1.3 - 6.91 @ 20 °C and pH 7.1 - 8.8 [12]

Type of Study provided
Studies with data
Key study 1 11
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 13 studies submitted
  • 12 studies processed
R Water solubility (mass/vol.)
125 - 8 700 000 µg/L @ 20 - 21 °C and pH 7.1 - 8.8 [12]

Type of Study provided
Studies with data
Key study 1 11
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Study results
  • 8 studies submitted
  • 8 studies processed
R N-octanol
22 - 1 000 g/L @ 20 °C [8]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 4 studies submitted
  • 2 studies processed
R Surface tension
25.2 - 26.5 mN/m @ 1 g/L and 25 °C [2]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 6 studies submitted
  • 4 studies processed
R Flash point
91 - 158 °C @ 101.3 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 5 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
215 - 255 °C @ 10.037 - 1 023.5 hPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 5 studies submitted
  • 4 studies processed
C Interpretation of results
Non flammable (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Non-explosive (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
9.78 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
2.29 - 3.84 [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 24 studies submitted
  • 8 studies processed
C Interpretation of results
Readily biodegradable (88%), Inherently biodegradable (13%) [8]

Type of Study provided
Studies with data
Key study 2 7
Supporting study 3 12
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
14.8 days @ 12 °C
Half-life in freshwater sediment
16.9 days @ 12 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
16.9 days @ 12 °C

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 260 ng/L (1)
Intermittent releases (freshwater) 260 ng/L (1)
Marine water 30 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 130 µg/L (1)
Sediment (freshwater) 1.25 mg/kg sediment dw (1)
Sediment (marine water) 125 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 1 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 16 studies submitted
  • 8 studies processed
P/RResults
LC50 (4 days) 180 - 1 130 µg/L [8]
LC50 (72 h) 350 µg/L [2]
LC50 (48 h) 430 - 1 000 µg/L [3]
LC50 (24 h) 430 µg/L [2]
LC0 (4 days) 180 - 800 µg/L [4]

Type of Study provided
Studies with data
Key study 2 6
Supporting study 2 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 8 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 55.8 - 926 µg/L [5]
EC50 (24 h) 160 - 400 µg/L [1]
LC50 (48 h) 42 µg/L [1]
EC0 (48 h) 60 µg/L [1]
EC0 (24 h) 160 - 280 µg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 36 - 108 µg/L [3]
LOEC (21 days) 108 - 200 µg/L [2]
EC10 (21 days) 200 µg/L [1]
EC50 (21 days) 141 - 310 µg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 10 studies submitted
  • 7 studies processed
P/RResults
EC50 (72 h) 16 - 56 000 ng/L [14]
NOEC (72 h) 500 - 20 000 ng/L [7]
EC10 (72 h) 25 - 8 520 ng/L [7]
EC90 (72 h) 38 - 78.6 µg/L [2]

Type of Study provided
Studies with data
Key study 7
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
16.5 µg/L
EC10 or NOEC for freshwater algae
2.6 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 9 studies submitted
  • 5 studies processed
P/RResults
EC50 (3 h) 13 - 80 mg/L [5]
EC10 (3 h) 5.6 - 50 mg/L [4]

Type of Study provided
Studies with data
Key study 5
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
13 mg/L

Sediment toxicity

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 62.5 mg/kg sediment dw [1]
NOEC (72 h) 1 620 mg/kg sediment dw [1]
LOEC (28 days) 125 mg/kg sediment dw [1]
LOEC (72 h) 2 030 mg/kg sediment dw [1]
EC50 (28 days) 169 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
62.5 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (56 days) 125 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw
Long-term EC10 / LC10 / NOEC
125 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 10 - 100 mg/kg soil dw [3]
EC50 (21 days) 120 - 700 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
10 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/m³ -
Acute /short term: (DNEL) 1 mg/m³ -
Local Effects
Long-term: (DNEL) 1 mg/m³ skin irritation/corrosion
Acute /short term: (DNEL) 1 mg/m³ skin irritation/corrosion
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
Local Effects
Long-term: (Medium hazard (no threshold derived)) -
Acute /short term: (Medium hazard (no threshold derived)) -
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 10
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Acute toxicity

Study results
oral
  • 15 studies submitted
  • 11 studies processed
P/RResults
LD50 1 000 - 2 118 mg/kg bw (rat) [15]
M/CInterpretations of results
Toxic [1]

Type of Study provided
oral
Studies with data
Key study 2 9
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 15
Supporting study 2 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2 2
Supporting study 2 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 8 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 42.3 - 52.6 mg/kg bw/day [2]
NOEL (rat): 40 - 50 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2 8
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant