Registration Dossier
Registration Dossier
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EC number: 231-599-9 | CAS number: 7647-15-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Only few data on test method are reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 935
Materials and methods
- Principles of method if other than guideline:
- An acute oral toxicity test was performed with sodium bromide. Doses between 2000 and 5000 mg/kg bw were administered by stomach tube to albino rats.
- GLP compliance:
- no
- Test type:
- other: Only few details on the test method are reported.
- Limit test:
- no
Test material
- Reference substance name:
- Sodium bromide
- EC Number:
- 231-599-9
- EC Name:
- Sodium bromide
- Cas Number:
- 7647-15-6
- Molecular formula:
- BrNa
- IUPAC Name:
- Active bromine generated from sodium bromide and sodium hypochlorite
- Details on test material:
- - Name of test material (as cited in study report): sodium bromide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats.
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: from 100 to 200 g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Sodium bromide was administered by stomach tube to the rats.
- Doses:
- Between 2000 and 5000 mg/kg bw.
- No. of animals per sex per dose:
- Groups of 1, 2, 20 and 42 animals.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 in rats is 3500 mg/kg bw.
- Executive summary:
In the present study, male and female albino rats were exposed to concentrations ranging from 2000 to 5000 mg/kg of sodium bromide in order to determine the dose causing death to 50 per cent of the treated animals (LD50). The test substance was administered by stomach tube. The oral LD50 in rats was determined to be 3500 mg/kg.
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