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Diss Factsheets
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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: GLP study similar to guideline but with distinct deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- five male and five female rats per dose group were used, no bodyweight measurement, no necropsy performed
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF-derived albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Breeding Unit, ICI Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, UK
- Weight at study initiation: 119-220 g
- Fasting period before study: 16-20 h
- Housing: in stainless steel cages with a maximum of 5 animals per cage
- Diet (e.g. ad libitum): BP PCD pellets ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23°C
- Humidity (%): 50-60%
- Air changes (per hr): 24
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorso-lumbar region
- coverage: 75x50 mm
- Type of wrap if used: aluminium foil patch held in place by adhesive polyethylene tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with cotton-wool soaked in lukewarm water
- Time after start of exposure: 24h
TEST MATERIAL
- Concentration (if solution): 2 mL/kg bw (= 100%), 50% and 10%
- Constant volume used: yes - Duration of exposure:
- 24 h
- Doses:
- 2 mL/kg bw (= 100%), 50% and 10%
- No. of animals per sex per dose:
- 5 male and 5 female animals per dose group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 0% of mortality at 1000 mg/kg; 100% of mortality at 2mL/kg.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 0% of mortality at 200 mg/kg; 100% of mortality at 2mL/kg.
- Mortality:
- Cumulative mortality data are given in table 1.
- Clinical signs:
- other: Signs of toxicity included incontinence, scouring, dehydration, subdued behavior, curvature of the spine, unsteady gait, nervous appearance, piloerection, and increased vocalisation when handled. At 1000 mg/kg bw the clinical signs described above were o
Any other information on results incl. tables
Table 1: Cumulative mortality in male rats after dermal exposure to cyhalothrin.
Time after dosing |
Dose [mg/kg bw] and cumulative mortality |
||
200 |
1000 |
2 mL |
|
day 1 |
0/5 |
0/5 |
0/5 |
day 2 |
0/5 |
0/5 |
0/5 |
day 3 |
0/5 |
0/5 |
0/5 |
day 4 |
0/5 |
0/5 |
2/5 |
day 5 |
0/5 |
0/5 |
4/5 |
day 7 |
0/5 |
0/5 |
5/5 |
day 15 |
0/5 |
0/5 |
5/5 |
Table 2: Cumulative mortality in female rats after dermal exposure to cyhalothrin.
Time after dosing |
Dose [mg/kg bw] and cumulative mortality |
||
200 |
1000 |
2 mL |
|
day 1 |
0/5 |
0/5 |
0/5 |
day 2 |
0/5 |
0/5 |
0/5 |
day 3 |
0/5 |
2/5 |
0/5 |
day 4 |
0/5 |
2/5 |
1/5 |
day 5 |
0/5 |
2/5 |
3/5 |
day 7 |
0/5 |
2/5 |
5/5 |
day 15 |
0/5 |
2/5 |
5/5 |
Applicant's summary and conclusion
- Conclusions:
- It was not possible to estimate the LD50 (rat, dermal) of cyhalothrin. The value of LD50 must be in the range of LD0 -LD100, that means 1000 mg/kg bw -2mL/kg bw in male rats and 200 mg/kg bw -2mL/kg bw in female rats.
- Executive summary:
Acute dermal toxicity of cyhalothrin to rats was determined in an in vivo test on male and female animals similar to OECD Guideline 402. Dose range was 200 mg/kg bw - 2mL/kg bw. GLP compliance was stated.
Clinical signs included incontinence, scouring, dehydration, subdued behavior, curvature of the spine, unsteady gait, nervous appearance, piloerection, and increased vocalisation when handled. No animal died in the 200 mg/kg bw dose group. In the 1000 mg/kg bw group, no male but two females died. All animals were found dead in the 2 mL/kg bw group; deaths occurred on days 4-7. It was not possible to estimate the LD50 (rat, dermal) of cyhalothrin. The value of LD50 must be in the range of LD0 -LD100, that means 1000 mg/kg bw -2mL/kg bw in male rats and 200 mg/kg bw -2mL/kg bw in female rats.
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