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EC number: 617-903-6 | CAS number: 86675-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP comparable to guideline study, available as unpublished report, adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (11E)-11,12-dibromo-7-(chloromethyl)-2,6,9,14,18-pentaoxanonadec-11-ene-4,16-diol; (12E)-12,13-dibromo-1,21-dichloro-8-(chloromethyl)-5,17-bis(methoxymethyl)-4,7,10,15,18-pentaoxahenicos-12-ene-2,20-diol; (8E)-8,9-dibromo-13-(hydroxymethyl)-2,6,11,15-tetraoxahexadec-8-en-4-ol; (8E)-8,9-dibromo-2,6,11,15-tetraoxahexadec-8-ene-4,13-diol
- EC Number:
- 617-903-6
- Cas Number:
- 86675-46-9
- Molecular formula:
- (C4H9O2)xC4H4O2Br2(C4H9O2)y with (x+y)= 2.5
- IUPAC Name:
- (11E)-11,12-dibromo-7-(chloromethyl)-2,6,9,14,18-pentaoxanonadec-11-ene-4,16-diol; (12E)-12,13-dibromo-1,21-dichloro-8-(chloromethyl)-5,17-bis(methoxymethyl)-4,7,10,15,18-pentaoxahenicos-12-ene-2,20-diol; (8E)-8,9-dibromo-13-(hydroxymethyl)-2,6,11,15-tetraoxahexadec-8-en-4-ol; (8E)-8,9-dibromo-2,6,11,15-tetraoxahexadec-8-ene-4,13-diol
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): IXOL M125
- Physical state: treacly liquid
- Lot/batch No.: 1013
- Purity: >99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: TNO, Zeist, The Netherlands
- Weight at study initiation: 180-200 g at arrival
- Fasting period before study: 16 hours before dosing until 6 hours after dosing
- Housing: continuously in stainless steel wire cages with 5 animals per cage
- Diet: a standard laboratory diet RMH-TM, Hope Farms, Woerden, The Netherlands
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 40-50
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% tragacanth
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 mL/kg - Doses:
- 250, 500, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed the first half an hour and at 1.5, 3, 6, 24 and 48 hours after dosing and thereafter on each day till the end of the experiment. The rats were weighed one day before and at 2, 7 and 14 days after dosing.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 and 95% CI were calculated according to the method of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 917 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 490 - <= 1 715
- Mortality:
- 4 rats died in the 2000 mg/kg bw group; 3 animals died in the 1000 mg/kg bw group and 1 animal died in 500 mg/kg bw group.
- Clinical signs:
- other: The signs were mainly indicative of effects on the autonomic nervous system (ptosis, diminished respiratory rate, respiratory difficulties, piloerection and hypothermia), on the central nervous system (apathy and positional passivity), on motor coordinati
- Gross pathology:
- Autopsy of rats that died as a result of treatment, revealed effects on the gastro-intestinal tract (irritation), kidneys (pale), liver (pale), lungs (red spots) and thymus (red spots). In the surviving animals no abnormalities were detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 = 917 (490-1715) mg/kg bw in male rats.
- Executive summary:
In a GLP compliant acute oral toxicity study, performed according to a protocol similar to the OECD guideline 401, male Wistar rats (5/dose) were exposed to 250, 500, 1000, and 2000 mg/kg bw of Polyol IXOL M125. At 250 mg/kg bw no mortalities were observed; at 500 mg/kg bw, 1 animal died; at 1000 mg/kg bw: 3 animals died and 2000 mg/kg bw: 4 animals died. In survivors, in the first days after dosing there was a weight loss in all dose groups, except the 250 mg/kg bw group. Thereafter there was a recovery. Clinical signs were mainly indicative of effects on the autonomic nervous system (ptosis, diminished respiratory rate, respiratory difficulties, piloerection and hypothermia), on the central nervous system (apathy and positional passivity), on motor coordination (abnormal gait, abnormal body posture, diminished locomotor activity, loss of righting-reflex) and on muscle tone (decreased abdominal and limb tone and paralysis). Autopsy of rats that died as a result of treatment, revealed effects on the gastro-intestinal tract (irritation), kidneys (pale), liver (pale), lungs (red spots) and thymus (red spots). In the surviving animals no abnormalities were detected. The LD50 was determined to be 917 mg/kg bw.
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