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EC number: 691-963-1 | CAS number: 761441-54-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 April 2014 -- 27 May 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- lithium(1+) 4,5-dicyano-2-(trifluoromethyl)-1H-imidazol-1-ide
- EC Number:
- 691-963-1
- Cas Number:
- 761441-54-7
- Molecular formula:
- C6 F3 N4. Li
- IUPAC Name:
- lithium(1+) 4,5-dicyano-2-(trifluoromethyl)-1H-imidazol-1-ide
- Test material form:
- other: white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: breeder: Janvier, Le Genest-Saint-Isle, France
- Age/Mean body weight at study initiation: on the day of treatment, the animals were approximately 8 (groups 1 and 3) or 9 (group 2) weeks. The males had a mean body weight of 370 g (range: 354 g to 380 g) and the females had a mean body weight of 215.4 g (range: 206 g to 230 g).
- Fasting period before study: yes, during the night before treatment
- Housing: polycarbonate cages
- Diet: SSNIFF R/M-H pelleted diet (free access)
- Water: tap water filtered with a 0.22 µm filter (free access)
- Acclimation period: at least 5 days before the beginning of the study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C
- Humidity (%): 50 ± 20%
- Air changes (per hr): approximately 12 cycles/hour of filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12 h/12 h
IN-LIFE DATES: 23 April 2014 to 27 May 2014
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 10% of body surface, dorsal site
- Type of wrap if used: hydrophilic gauze pad + adhesive hypoallergenic aerated semi-occlusive dressing + restraining bandage
REMOVAL OF TEST SUBSTANCE
- Removal of dressing: 24h post-exposure
- Washing: at 24h post-exposure, with a moistened cotton pad with water for injection (only in females)
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Constant volume: no - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Ten Sprague-Dawley rats (five males and five nulliparous and non pregnant females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Clinical observations: frequently during the hours following treatment; then, at least once a day.
- Body weight: just before treatment, on day 1; then on days 8 and 15.
- Necropsy of survivors performed: yes (macroscopic).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No unscheduled deaths occurred during the study.
- Clinical signs:
- other: No clinical signs indicative of systemic toxicity were observed in any animals and no cutaneous reactions were observed in males. An erythema was noted in all females from Day 2 or 3 until Day 7 at the latest or on Day 7 only and was associated with dryne
- Gross pathology:
- There were no macroscopic findings at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the experimental conditions of this study, the dermal LD50 of the test item was higher than 2000 mg/kg in rats. Since there was no mortality in the study, the dermal LD0, was also higher than 2000 mg/kg in rats.
Therefore, the test item should not be classified for the acute dermal toxicity according to the criteria of CLP Regulation. - Executive summary:
The objective of this study was to evaluate the potential toxicity of Lithium 4,5-dicyano 2-(trifluomethyl) imidazolate following a single dermal application to rats. This study was conducted in compliance with OECD Guideline No. 402 and the principles of Good Laboratory Practices. The test item was applied in its original form to the skin of one female in the first instance, after four female then five male Sprague-Dawley rats at the dose-level of 2000 mg/kg. The application site was covered by a semi-occlusive dressing for 24 hours. Each animal was observed at least once a day for mortality and clinical signs for 15 days. From Day 2, any local reactions at the treatment site were also noted. Body weight was recorded on Day 1 and then on Days 8 and 15. On completion of the observation period, the animals were sacrificed and then submitted for a macroscopic post-mortem examination. No tissues were preserved.
No unscheduled deaths occurred during the study. No clinical signs indicative of systemic toxicity were observed in any animals. No cutaneous reactions and no body weight changes were observed in males. An erythema was noted in all females from Day 2 until Day 7 at the latest. This was associated with dryness from Day 3 until Day 15 at the latest. On Day 15, a lower body weight and a lower body weight gain between Day 1 and Day 15 were noted in females. The test item did not induce any macroscopic findings at necropsy.
Under the experimental conditions of this study, the dermal LD50 of Lithium 4,5-dicyano 2-(trifluomethyl) imidazolate was higher than 2000 mg/kg in rats. Since there was no mortality in the study, the dermal LD0, was also higher than 2000 mg/kg in rats.
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