Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 231-099-0 | CAS number: 7439-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For the purposes of human risk assessment, oral absorption of lanthanum metal is estimated at 100%, inhalation absorption is estimated at 100% and dermal absorption is not expected to occur.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Introduction
The substance is a dark grey or silver coloured solid. No experimental studies with animals or humans on absorption, metabolism, distribution, or elimination are available for the substance. However, information is available from existing toxicology studies to infer potential toxicokinetic properties. Systemic availability of lanthanum depends on its ability to be absorbed across body surfaces. A major factor affecting this process is water solubility. Lanthanum readily reacts vigorously with water to form lanthanum hydroxide, La(OH)3, which is reportedly insoluble in water and becomes soluble in acid. Based on the known properties of other rare earth metals (e.g. neodymium) lanthanum would react in the stomach to form LaCl3 which is soluble. The melting point of lanthanum is 920ºC. The substance has a molecular weight of 138.9 g/mol.
Absorption
Oral absorption
Absorption via the oral route is unknown. Therefore, in the absence of information, and unknown effect of the acidity on the stomach, 100% bioavailability is assumed.
Dermal absorption
No studies investigating the absorption through the skin were available. In contact with normal dry skin the bulk metal is unlikely to hydrolyse at a sufficient rate that might allow bioavailability, before it is removed. No dermal absorption is expected to occur.
Inhalation absorption
No inhalation studies are available. For any inhaled particles that make it to the alveoli, hydrolysis and formation of more finely divided colloid of the hydroxide is likely to occur. In the absence of any quantitative or qualitative information on inhalation absorption, 100% absorption is assumed.
Distribution and metabolism
No information is available.
Conclusion
For the purposes of human risk assessment oral absorption of lanthanum metal is estimated at 100%, inhalation absorption is estimated at 100% and dermal absorption is not expected to occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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