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EC number: 204-688-5 | CAS number: 124-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980-12-01 to 1980-12-29
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Inadequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 10 rabbits (5 male, 5 female) dermally exposed to repeat doses of 500 mg/kg bw/d for 5 consecutive d/wk for 2 wks
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Nonanal
- EC Number:
- 204-688-5
- EC Name:
- Nonanal
- Cas Number:
- 124-19-6
- Molecular formula:
- C9H18O
- IUPAC Name:
- nonanal
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): C9 aldehyde; C-192
- Substance type: Colourless liquid
- Physical state: Liquid
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: Room temperature under nitrogen blanket
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dutchland Laboratory Animals, Denver, Pennsylvania, United States
- Age at study initiation: Young adults
- Weight at study initiation: Males 2.1 to 3.2 kg; females 2.3 to 3.2 kg
- Fasting period before study:
- Housing: Individually in suspended stainless steel cages
- Diet: Ad libitum rabbit chow
- Water: Ad libitum mains water
- Acclimation period: 21 d
ENVIRONMENTAL CONDITIONS
- Temperature: 60 to 70 °F (i.e. (16 to 21 °C)
- Humidity (%): Monitored daily
- Air changes (per hr): No data
- Photoperiod: 12 hrs dark / 12 hrs light
Administration / exposure
- Vehicle:
- other: Mineral oil
- Details on exposure:
- TEST SITE
- Area of exposure: Dermal and lateral skin, approx. 10 % of body area.
- Time intervals for shavings or clipplings: Before first exposure, as necessary during test period.
- Abrasion of the skin of animals prior to the 1st, 6th and 8th doses unless otherwise integrity of the skin had already been compromised due to a response to the test material.
- No covering was applied.
- Test material in vehicle was spread evenly over the exposure site with a glass rod.
TEST MATERIAL IN VEHICLE
- Dosage applied: 500 mg/kg bw/d of test material
- Concentration: 25 % in vehicle solution
- Doses adjusted weekly on the basis of most recent body weight data.
RESTRAINERS FOR PREVENTING INGESTION
- Elizabethan collars. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 2 wks
- Frequency of treatment:
- Daily for 5 d/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mg/kg bw
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 5 male, 5 female per single dose
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale:
- Rationale for animal assignment: Random
Examinations
- Sacrifice and pathology:
- SACRIFICE
- 2 wks: 6 animals (3 with abraded skin, 3 with intact skin, regardless of sex)
- 4 wks: All survivors
- Method: Exsanguination under sodium pentobarbital anaesthesia.
HISTOPATHOLOGY
- Tissues preserved in 10 % neutral buffered formalin: Adrenals (2), brain (2 sections), eyes, gonads, heart, intestine (colon, duodenum, ileum), kidneys (2), liver (2), lungs (2), lymph node (mesenteric), mammary gland, pancreas, pituitary, salivary gland, skeletal muscle, skin (both treated and untreated sections), spinal chord (cervical), spleen, stomach, thyroid, urinary bladder, uterus/prostate, gross lesions, tissue masses.
- Slides prepared from tissues, stained with haematoxylin and eosin, and examined microscopically: Brain (2 sections), heart, skin (both treated and untreated sections), kidneys (2), liver (2), lungs (2). - Statistics:
- None.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- CLINICAL SIGNS AND MORTALITY
- No mortality.
- Nasal discharge and vocalisation when handled were noted occasionally.
- No unusual signs other than the dermal observations listed below were seen during the recovery period.
BODY WEIGHT AND WEIGHT GAIN
- Most animals exhibited slight weight loss (0.1 to 0.6 kg) after 1 and/or 2 weeks of study.
- Animals held for a recovery period gained weight during this interval.
FOOD CONSUMPTION
- Several animals exhibited decreased food consumption, primarily during the 2nd and 3rd weeks.
GROSS PATHOLOGY
- Morphological abnormalities of the treated skin were observed more frequently in rabbits from the test group than in the control group.
- Discolourations of gastric mucosa were observed in several of the treated animals [NB: it is not clear to what extent this statement applies to the test material of interest versus the other test materials tested concurrently].
- Other morphological findings observed grossly occurred sporadically in the treated and/or control animals. They did not appear to be related to the administration of the test compounds [NB: it is not clear to what extent this statement applies to the test material of interest versus the other test materials tested concurrently].
HISTOPATHOLOGY: NON-NEOPLASTIC
- Epidemial necrosis was present in the application sites of animals from the treatment group. This was generally less severe and more localised than groups concurrently treated with two other substances and was accompanied by epidermal hyperplasia and hyperkeratosis. Diffuse and perifollicular dermal inflamation was also common.
- The skin application sites in all surviving animals appeared healed by 2 wks post-treatment (scheduled recovery period). In all cases the sites were re-epitheliased and continuous; they also revealed mild to moderate epidemial hyperplasia and hyperkeratosis as well as normal follicular structure and population.
Effect levels
- Basis for effect level:
- other: No NOAEL identified as effects seen at single dose level of 500 mg/kg bw/d.
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The test substance was assessed for repeat dose dermal toxicity in rabbits. No NOAEL was identified as effects were seen at the single dose level of 500 mg/kg bw/d.
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