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EC number: 204-407-6 | CAS number: 120-55-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
Studies were conducted to determine the acute toxicity of the test material DEGDB to freshwater fish (Rainbow Trout and Fathead minnow). The studies were conducted according to EC, OECD, and US EPA test guidelines, and in compliance with GLP.
The 96 h LL50 value for DEGDB with rainbow trout was 2.9 mg/L, with the "no-observed effect loading rate" (NOELR) of 0.06 mg/L (HLS 2001, VCL243/974218).
The 96 h LL50 value with fathead minnow was 3.9 mg/L and the NOELR was 1.5 mg/L (HLS 2001, VCL244/974219).
For chemical safety assessment, the lowest value is chosen and therefore the LL50 of DEGDB for freshwater fish is 2.9 mg/L. The 96h LL50 to freshwater fish is shown to be <10 mg/L.
Long term toxicity to fish
This study is proposed to be waived, based on the short-term testing results and the rapid biodegradability of the substance.
Short-term toxicity to aquatic invertebrates
One study is available and valid.
An acute Daphnia Immobilisation study was performed to determine the acute toxicity to Daphnia of the test material DEGDB (HLS 2001, VCL264/974222). The study was conducted according to EC, OECD, and US EPA test guidelines, and in compliance with GLP. The 48 hour EL50 (immobilisation value for DEGDB with Daphnia Magna) was determined to be 6.7 mg/L. The NOELR was 1.0 mg/L.
Long-term toxicity to aquatic invertebrates
This study is proposed to be waived, based on the short-term testing results and the rapid biodegradability of the substance.
Toxicity to aquatic algae and cyanobacteria
An algal growth inhibition test was conducted to determine the effect on the growth of algae of the test material DEGDB (HLS 2001, VCL265/974223). The study was conducted according to EC, OECD, and US EPA test guidelines, and in compliance with GLP.
The 72h EL50 (Area under the curve, biomass) was 5.2 mg/L and the 72h EL50 (Growth rate) was 11 mg/L. The corresponding NOELR were 2.2 mg/L and 1.0 mg/L, respectively.
Toxicity to aquatic plants other than algae
No data available. No data required.
Toxicity to microorganisms
An activated sludge respiration inhibition test was conducted to determine the effect on sewage micro-organisms of the test material DEGDB (HLS 1998, VCL245/970386). The study was conducted in accordance with EC, OECD, and US EPA test guidelines, and in compliance with GLP.
DEGDB had no significant inhibitory effect on the respiration rate of activated sludge at any of the concentrations employed in the tests. The EC20 and EC50 of the test material could not therefore be calculated but these must be greater than 100 mg/L, the highest tested level.
A second study that supports these results was performed to assess the effect of DEGDB on the growth of the bacteria Pseudomonas putida (Safepharm 1998, 1104/002). The method followed that described in the German Water Hazard Classification Scheme Bewertung Wassergefahrdender Stoffe LTWS Nr 10 and ISO 10712, and was conducted to GLP.
Exposure of Pseudomonas putida to DEGDB gave EC10 and EC50 values of greater than 10 mg/L. The "no-observed effect level" (NOEC) was >= 10 mg/L.
Toxicity to other microorganisms
No data available. No data required.
Conclusion
The acute toxicity to aquatic organisms was investigated in (i) freshwater fish (2 species), (ii) in Daphnia magna and (iii) in green algae.
The results were as follows:
(i). The 96h LL50 to freshwater fish was determined to be 2.9 mg/L.
(ii). The 48 hour EL50 (EC50) immobilisation of Daphnia magna was determined to be 6.7 mg/L.
(iii). For algal growth inhibition, Selenastrum capricornutum, the 72h EL50 was 11 mg/L and 5.2 mg/L for growth rate and area under the curve (biomass), respectively. The "no-observed effect loading rate" (NOELR) at 72 hours was 2.2 mg/L and 1.0 mg/L for growth rate and area under the curve (biomass), respectively.
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