Registration Dossier
Registration Dossier
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EC number: 230-796-7 | CAS number: 7324-02-9
Endpoint summary
Administrative data
Description of key information
REACH_slightly irritating | rabbit | OECD 404 | #Analogy#
REACH_irritating | rabbit | OECD 405 |#Analogy (ethylcyanoacrylate)#
Based on in vivo studies with ethyl 2-cyanoacrylate (ECA), the substance has to be classified as skin and eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Allyl 2-cyanoacrylate is a structural analogue to 2-ethyl cyanoacrylate. Both substances share the reactive cyanoacrylate function. The chain length of the alcohol moiety in allyl cyanoacrylate is only slightly different compared to 2-ethyl cyanoacrylate thus it can be considered that both have similar toxicological properties
Skin irritation:
In an OECD 404 guideline study with New Zealand rabbits a slightly irritating property of ethyl 2-cyanoacrylate was shown with a primary dermal irritation index (PDII) of 0.87 (mean). Hence, ethyl 2-cyanoacrylate is not considered to be skin irritating. However, based on CLP Regulation (EC) No 1272/2008, Annex VI, Table 3, ethyl 2-cyanoacrylate requires classification as Skin Irrit. 2. H315.
Eye irritation:
Ethyl 2-cyanoacrylate was tested in an OECD 405 guideline study resulting in in an overall irritation score of 29.33 (mean) with reversibility within 24 hours. Based on this study, ethyl 2-cyanoacrylate is considered eye irritating and classified as Eye Irrit. 2, H319.
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