Allyl 2-cyanoacrylate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Justification for type of information:

Test not performed because allyl 2-cyanoacrylate is highly reactive to water resulting in fast polymerization process (in seconds) thus the nature of the substance does not allow to be tested for the endpoint Acute toxicity: dermal.
The physico-chemical characteristics of allyl 2-cyanoacrylate:
- dramatically limit or exclude testing of certain assays since its reactivity with water results immediately into a polymer;
- may also prevent administration of precise and consistent doses of the chemical for both in vitro studies and in vivo studies
as it is described in the Guidance on information requirements and chemical safety assessment Chapter R.5: Adaptation of information requirements chapter (R.5.2.2 Testing is technically not possible (page 28)) the waiver is herewith justified.
Conform Annex XI section 2 of REACH it is possible omit any required information under the justification that testing is technically not possible.

Applicant's summary and conclusion

Conclusions:

Study technically not feasible: test substance would polymerize immediately.

Executive summary:

Tests in aqueous media with allyl 2-cyanoacrylate with the intent to determine a LD50 value cannot be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture allyl 2-cyanoacrylate polymerizes within seconds (inherent property of 2-cyanoacrylate based instant glues). The monomer would polymerize on the skin which allows only the polymer to be tested.