Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 686-016-4 | CAS number: 881302-73-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 5-(dihydroxyboranyl)benzene-1,3-dicarboxylic acid
- Cas Number:
- 881302-73-4
- Molecular formula:
- C8H7BO6
- IUPAC Name:
- 5-(dihydroxyboranyl)benzene-1,3-dicarboxylic acid
- Test material form:
- solid
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- ca. 50.112 µm
- Geometric standard deviation:
- ca. 2.338
Particle sizeopen allclose all
- Key result
- Percentile:
- D90
- Mean:
- ca. 96.1 µm
- St. dev.:
- 1.68
- Key result
- Percentile:
- D50
- Mean:
- ca. 39.3 µm
- St. dev.:
- 0.269
- Key result
- Percentile:
- D10
- Mean:
- ca. 16.3 µm
- St. dev.:
- 0.068
Particle size distribution at different passagesopen allclose all
- No.:
- #5
- Size:
- ca. 39.3 µm
- Distribution:
- ca. 50 %
- No.:
- #4
- Size:
- ca. 38.8 µm
- Distribution:
- ca. 50 %
- No.:
- #3
- Size:
- ca. 39.4 µm
- Distribution:
- ca. 50 %
- No.:
- #2
- Size:
- ca. 39.5 µm
- Distribution:
- ca. 50 %
- No.:
- #1
- Size:
- ca. 39.3 µm
- Distribution:
- ca. 50 %
Any other information on results incl. tables
During the method development phase of the analysis trials were
conducted using the small volume (wet) module (SVM). The SVM trials were
conducted using silicone oil as the dispersant. The results of these
trials indicated that the most appropriate test and material parameters
to obtain the optimum measurements were:
Module : SVM
Dispersant : Silicone oil
Dispersion speed : 1500 rpm
Refractive index (sample) : 0.000 n
Absorption : 0.000 AU
Analysis Model : General Purpose
Using the identified parameters, the particle size was analysed over the
range 0.01 μm to 3500 μm. The results of the formal analysis are
presented in Table 10:1. In addition, a graph of volume (%) versus
Particle Diameter (μm), and full particle size distribution, is provided
in Graph 10.A (Average of 5 runs).
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
Average |
STDVP % |
STDVP |
VWM |
49.2 |
48.5 |
49.9 |
48.5 |
49.8 |
49.2 |
N/A |
N/A |
Mode |
38.1 |
38.5 |
37.8 |
37.6 |
38.0 |
38.0 |
N/A |
N/A |
d10 |
16.3 |
16.3 |
16.4 |
16.2 |
16.4 |
16.3 |
0.0679 |
0.416 |
d50 (Median) |
39.3 |
39.5 |
39.4 |
38.8 |
39.3 |
39.3 |
0.269 |
0.685 |
d90 |
96.7 |
94.1 |
97.8 |
94.6 |
97.5 |
96.1 |
1.68 |
1.74 |
MMAD |
50.160 |
50.367 |
50.319 |
49.519 |
50.207 |
50.112 |
0.307 |
0.6 |
GSD |
2.349 |
2.326 |
2.344 |
2.327 |
2.345 |
2.338 |
0.010 |
0.4 |
All particle size results are in μm
4.82 % by volume of sample was seen to be < 10.00 μm
Definitions
VWM : volume weighted mean
d10 : 10 % of the test item is less than this particle size
d50 : 50 % of the test item is less than this particle size
d90 : 90 % of the test item is less than this particle size
GSD : geometric standard deviation of the lognormal particle size
distribution
MMAD : mass median aerodynamic diameter
Average : calculated from the entirety of the data captured in each run and not
a simple arithmetic mean
STDVP : standard deviation of the population
% STDVP : percentage standard deviation of the population
The coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus, repeatability of the characteristic particles in the size distribution is within the acceptable limits as per the ISO 13320-1 test standard.
Applicant's summary and conclusion
- Conclusions:
- Average STDVP % STDVP
VWM 49.2 N/A N/A
Mode 38.0 N/A N/A
d10 16.3 0.0679 0.416
d50 (Median) 39.3 0.269 0.685
d90 96.1 1.68 1.74
MMAD 50.112 0.307 0.6
GSD 2.338 0.010 0.4 - Executive summary:
The test is conducted to determine the particle size distribution of
3,5-Dicarboxyphenylboronic acid. The test item is initially observed to determine whether sieving of the material is required. A method development for the particle size analysis on the material is then undertaken to obtain the correct parameters for the formal analysis.
The method development is employed to identify the most appropriate optical properties for the material, the correct dispersant, dispersion pressures and sample compatibility. Once these parameters are obtained the test item is then analysed using the Malvern Mastersizer 3000 Laser Diffraction Analyser. It is normal practice to complete 5 runs to ensure repeatability of results. The test is conducted in accordance with ISO 13320:2009 “Particle Size Analysis – Laser Diffraction Methods”, 2009 and CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007.During the method development phase of the analysis trials were conducted using the small volume (wet) module (SVM). The SVM trials were conducted using silicone oil as the dispersant. The results of these trials indicated that the most appropriate test and material parameters to obtain the optimum measurements were:
Module : SVM
Dispersant : Silicone oil
Dispersion speed : 1500 rpm
Refractive index (sample) : 0.000 n
Absorption : 0.000 AU
Analysis Model : General Purpose
Using the identified parameters, the particle size was analysed over the range 0.01 μm to 3500 μm. The results of the formal analysis are presented in the following table:Average
STDVP %
STDVP
VWM
49.2
N/A
N/A
Mode
38.0
N/A
N/A
d10
16.3
0.0679
0.416
d50 (Median)
39.3
0.269
0.685
d90
96.1
1.68
1.74
MMAD
50.112
0.307
0.6
GSD
2.338
0.010
0.4
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.