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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 913-353-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Remarks:
- One GLP-compliant guideline study (OECD 203) is available for short-term toxicity in fish. The 96-h LC50 is 99 mg/L in zebra fish (Brachydanio rerio) in a static test; the concentrations were analytically verified (Solvay, 2008a).
- Adequacy of study:
- weight of evidence
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- guideline study available as unpublished report, no restrictions, fully adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
- Remarks:
- In the following is the data from the study available to determine the short-term toxicity of trisodium hexafluoroaluminate on fish.
Reference
No studies are available to determinate the toxicity to aquatic plants other than algae, of trisodium hexafluoroaluminate or calcium fluoride. Available studies on fluoride were used as read-across source. Effective concentrations were recalculated taking in account the different molecular weight of the source and target substance.
A 7 -day study was conducted on Lemna minor to assess the toxicity of fluoride in the presence of chloride and in hard water. Lemna minor was found to be relatively insensitive to fluoride with an IC50 value (frond number) of 391 mg/L F. This relates to 803.39 mg CaF2/L. and relates to 720 mg Na3AlF6/L
Reliable acute ecotoxicity test results are available for fish, invertebrates and algae. The 96-h LC50 in Brachydanio rerio is 99 mg/l from a GLP compliant OECD guideline study (Solvay, 2008a). An OECD guideline study is available for short-term toxicity in invertebrates, the 48-h EC50 in Daphnia magna is 156 mg/l (IWL, 1998). The 72-h ErC50 is 8.8 mg/l in the freshwater algae Pseudokirchneriella subcapitata (tested as Selenastrum capricornutum), the 72-h NOEC for growth rate is 1.0 mg/l from a GLP compliant OECD guideline study (Solvay, 2008b).
Long-term ecotoxicity tests with fish and invertebrates are not available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- In the protocol it is stated that the purity of the test substance is >99%. However, in the certificate of analysis the purity of the test substance is reported as 96.9%. Furthermore, two concentrations instead of five were tested
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- impurity
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Cryolite
- Substance type: slighty coloured powder
- Analytical purity: 96.9%
- Composition of test material, percentage of components: Na 31%, Al 12.6%, F 53.3%
- Storage condition of test material: room temperature
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Cryolite
- Substance type: slighty coloured powder
- Analytical purity: 96.9%
- Composition of test material, percentage of components: Na 31%, Al 12.6%, F 53.3%
- Storage condition of test material: room temperature
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- On day 0 samples were taken in duplicate from all test solutions. After 96 hours samples were taken in duplicate from all aquariums. The test solutions with a concentration of 100 and 150 mg/l were diluted 50 times with ISO water before analysis. The samples were stored at 2-8 °C for a maximum of 7 days.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Two days before test initiation a stock solution of 150 mg/l cryolite was prepared in duplicate by dissolving 601 mg in 4 litre ISO water. These stock solutions were continuously stirred for four days at 20 °C. On the day of test initiation the solution was filtered with filter paper (S&S 595 1/2) to remove undissolved particles
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Common name: zebra fish (Brachydanio rerio)
- Source: De Rifwachter, Hilversum, The Netherlands
- Food type: living water fleas and Tetramin
- Mean weight per fish: 0.452 gram
- Weight of the fish per litre test solution was lower than 1.0 gram
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Not specified
- Test temperature:
- 22.8 - 23.8 °C
- pH:
- 7.1
- Dissolved oxygen:
- 8.0 - 8.3 mg/l
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal: 0, 100 and 150 mg/l
Measured: 0, 73 and 99 mg/l - Details on test conditions:
- One aquarium (length, width and height of 30, 20 and 15 cm respectively) was prepared per test concentration containing 4 litre test solution and 8 zebra fish. The aquariums were covered with plastic plates. The test solutions were continuously aerated during the test. The light regime was 14 hours light and 10 hours dark. The zebra fish were not fed during the test.
OBSERVATIONS
24, 48, 72 and 96 hours after test initiation the behaviour and appearance of the surviving fish was recorded. On day 0 the pH, oxygen content and temperature of the ISO-water and the stock solution were measured. At test termination the water parameters were measured in all aquariums - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 95 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 99 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: behavior and general appearance
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 99 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: mortality and aberrant behavior
- Details on results:
- No mortality was observed in the control aquarium. At the tested concentrations the substance had no effect on mortaility, behavior and general appearance such as length of the fish.
Based on the certificate of analysis cryolite contains 53.3% fluoride. Based on these results, the difference between the nominal and the mean measured concentrations was >20% and for this reason the endpoints of the test were based on mean measured concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Because in RAL 3.0 Trisodium hexafluoroaluminate is present in a proportion of less than 1%, the preparation is not harmful
- Executive summary:
Reliable acute ecotoxicity test results are available for fish, invertebrates and algae. The 96-h LC50 in Brachydanio rerio is 99 mg/l from a GLP compliant OECD guideline study (Solvay, 2008a).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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