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EC number: 946-248-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 04, 2019 to November 11, 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- January 22, 2001
- Deviations:
- yes
- Remarks:
- The analysis of the solutions was repeated because the first time they could not be injected. The calibration mixture was prepared by adding directly exactly weighed portions of the ref subs to one flask containing eluent. (See details in results).
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- May 30, 2008
- Deviations:
- yes
- Remarks:
- The analysis of the solutions was repeated because the first time they could not be injected. The calibration mixture was prepared by adding directly exactly weighed portions of the ref subs to one flask containing eluent. (See details in results).
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC approach (OECD 121)
- Specific details on test material used for the study:
- Batch No. VE00571754
Purity: 99.7% (sum of the isomers)
Expiration date: March 18, 2020 - Radiolabelling:
- no
- Test temperature:
- The determination was performed at 25 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log KOC values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.
- Details on study design: HPLC method:
- Principle of the method :
Reverse phase High Performance Liquid Chromatography on cyanopropyl-modified silica stationary phase, containing lipophilic and polar moieties, is used.
While passing through the column among with the mobile phase the test substance interacts with the stationary phase. As a result of the partitioning between the mobile and stationary phase the test substance is retarded. The dual-composition of the stationary phase having polar and non-polar sites allows for interaction of polar and non-polar groups of a molecule in a similar way as it is the case for organic matter in soil or sewage sludge matrices. This enables the rela-tionship between the retention time on the column and the adsorption coefficient on organic matter to be established.
Equipment and conditions :
HPLC equipment: Perkin Elmer (series 200) HPLC system comprising:
- a high pressure pump (module N2910102, serial number: 291N8051901A)
- an auto-sampler (module N2930100, serial number: 293N8052404A)
- a column compartment (module N2601581, serial number: OVH0802151130)
- a refractive index detector (series 200a, serial number 125829).
- Column : 250 mm x 4.6 mm, Nucleodur 100-5 CN-RP
(Macherey-Nagel)
serial number: E15120578, batch 34514011
- Mobile phase : methanol / water 55/45 (v/v)
- Flow rate : 1.0 ml/min.
- Column temperature : 25 °C
- Injected volume : 100 µL
Reference substances :
Six substances were chosen having log KOC ranging from 1.45 to 5.63. Formamide is used as an unretained compound for the determination of the "dead time" t0.
On the day of the determination a calibration mixture of these seven substances in methanol / water 55/45 (v/v) was prepared.
Reference Substance LogKoc
Formamide dead-time
2-Nitrobenzamide 1.45
Methyl Benzoate 1.80
Naphthalene 2.75
1,2,3-Trichlorobenzene 3.16
Phenanthrene 4.09
4,4'-DDT 5.63
HPLC procedure:
A solution of the test substance was prepared (10.0 mg in 10.0 ml methanol/water 55/45 v/v). After equilibration of the HPLC system, the calibration mixture was injected first, followed by the test chemical solution twice and the calibration mixture again.
Retention times tr were measured and averaged and the decimal logarithms of the capacity factors k were calculated. The linear regression parameters of the relationship log Koc = f(log k) were also calculated from the data obtained with the calibration mixture and, therewith, log Koc of the test substance was determined from its measured capacity factor. - Type:
- log Koc
- Value:
- 4.1 dimensionless
- Temp.:
- 25 °C
- Matrix:
- HPLC method
- Remarks on result:
- other: around 3.4% of relative peak area
- Key result
- Type:
- log Koc
- Value:
- 4.3 dimensionless
- Temp.:
- 25 °C
- Matrix:
- HPLC method
- Remarks on result:
- other: around 83.8% of relative peak area
- Type:
- log Koc
- Value:
- 4.6 dimensionless
- Temp.:
- 25 °C
- Matrix:
- HPLC method
- Remarks on result:
- other: around 12.7% of relative peak area
- Details on results (HPLC method):
- Due to a technical failure on the chromatograph the solutions prepared on October 31 could not be injected as foreseen. The analysis was repeated on November 08, 2019. Only the results of this second, successful analysis are reported here in detail.
The calibration mixture was not prepared as foreseen in the study plan by mixing of individual solutions of the reference substances, but by directly adding exactly weighed portions of the reference substances to one flask containing the eluent. The validity of the study is not adversely affected.
The chromatograms of Sinodor CQ show three peaks at average rention times of 11.465 minutes, corresponding to an adsorption coefficient (log value) of 4.1 (around 3.4% relative peak area), 12.446 minutes, corresponding to an adsorption coefficient (log value) of 4.3 (around 83.8% relative peak area), and 15.147 minutes, corresponding to an adsorption coefficient (log value) of 4.6 (around 12.7% relative peak area). - Validity criteria fulfilled:
- yes
- Conclusions:
- The chromatograms of Sinodor CQ show three peaks at average rention times of 11.465 minutes, corresponding to an adsorption coefficient (log value) of 4.1 (around 3.4% relative peak area), 12.446 minutes, corresponding to an adsorption coefficient (log value) of 4.3 (around 83.8% relative peak area), and 15.147 minutes, corresponding to an adsorption coefficient (log value) of 4.6 (around 12.7% relative peak area).
Therefore: Adsorption coefficients (Koc) of Sinodor CQ:
log Koc = 4.1, 4.3 (main peak) and 4.6
N.B. : The determination was performed at 25 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log KOC values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way. - Executive summary:
The Adsorption coefficient (Koc) on soil and on sewage sludge of Sinodor CQ was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 121.
The result is:
Adsorption coefficients (Koc) of Sinodor CQ:
log Koc = 4.1, 4.3 (main peak) and 4.6
Reference
Description of key information
The chromatograms of Sinodor CQ show three peaks at average rention times of 11.465 minutes, corresponding to an adsorption coefficient (log value) of 4.1 (around 3.4% relative peak area), 12.446 minutes, corresponding to an adsorption coefficient (log value) of 4.3 (around 83.8% relative peak area), and 15.147 minutes, corresponding to an adsorption coefficient (log value) of 4.6 (around 12.7% relative peak area).
Therefore: Adsorption coefficients (Koc) of Sinodor CQ:
log Koc = 4.1, 4.3 (main peak) and 4.6
(N.B. : The determination was performed at 25 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log KOC values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way).
The determined Koc values suggests that SINODOR CQ will demonstrate strong sorption to soil and sediment, with negligible to slow migration potential to groundwater.
Key value for chemical safety assessment
- Koc at 20 °C:
- 19 953
Additional information
The chromatograms of Sinodor CQ show three peaks at average rention times of 11.465 minutes, corresponding to an adsorption coefficient (log value) of 4.1 (around 3.4% relative peak area), 12.446 minutes, corresponding to an adsorption coefficient (log value) of 4.3 (around 83.8% relative peak area), and 15.147 minutes, corresponding to an adsorption coefficient (log value) of 4.6 (around 12.7% relative peak area).
Therefore: Adsorption coefficients (Koc) of Sinodor CQ:
log Koc = 4.1, 4.3 (main peak) and 4.6.
The determined Koc values suggests that SINODOR CQ will demonstrate strong sorption to soil and sediment, with negligible to slow migration potential to groundwater.
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