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Diss Factsheets
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EC number: 437-450-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 29 July 1999 and 15 December 1999.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- OECD draft document (December 1998): Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC).
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: Not required
- Specific details on test material used for the study:
- No further details specified in the study report.
- Radiolabelling:
- no
- Test temperature:
- Column temperature: 30°C
- Details on study design: HPLC method:
- Procedure
Preparation of sample solution
Test material (0.1000 g) was diluted to 100 ml with methanol.
Preparation of reference solutions
The dead time was determined by measuring the retention time of formamide (purity 99.5%, 735 mg/l solution in methanol).
Determination of retention time
The sample, formamide and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC system: Hewlett-Packard 1050, incorporating autosampler and workstation
Column: Hypersil 5μ CN-BDS (250 mm x 4.6 mm id)
Column temperature: 30 °C
Mobile phase: methanol: water (55.45 v/v)
pH of mobile phase: 7.01
Flow-rate: 1 ml/min
UV detector wavelength: dead time and reference standards: 210 nm; sample: 217 nm
Injection volume: 10 μl
Construction of calibration curve
A calibration curve was constructed from the retention time data of the formamide and reference standard solutions. The capacity factors (k) for the reference standards were calculated.
Adsorption coefficient sf sample
The capacity factor was calculated using the log10 Koc value determined with reference to the calibration curve. - Key result
- Type:
- log Koc
- Value:
- 3.63 dimensionless
- pH:
- 7.01
- Temp.:
- 30 °C
- Key result
- Type:
- Koc
- Value:
- 4 240 dimensionless
- pH:
- 7.01
- Temp.:
- 30 °C
- Details on results (HPLC method):
- The draft document states that the measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However, the dissociation constant of APAN made it impossible to satisfy this criteria. Testing would be required at pH 0.6 or below for the material to be ionised which is outside the environmental pH range for this test.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The adsorption coefficient (Koc) of APAN has been determined to be 4.24 x 103, log10 Koc 3.63.
- Executive summary:
Adsorption coefficient determined as 4.24 x 103, log10 Koc 3.63, using the OECD draft document (December 1998): Estimation of the Adsorption Coefficient (K,) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC).
Reference
The retention times of formamide and the reference standards
Dead time |
Retention time (mins) |
Mean retention time (mins) |
|
Injection 1 |
Injection 2 |
||
Formamide |
3.285 |
3.287 |
3.286 |
Standard |
Retention time (mins) |
Mean retention time (mins) |
|
Injection 1 |
Injection 2 |
||
Acetanilide |
3.576 |
3.573 |
3.575 |
Phenol |
3.532 |
3.532 |
3.532 |
Atrazine |
4.087 |
4.088 |
4.088 |
Isoproturon |
4.293 |
4.295 |
4.294 |
Naphthalene |
5.403 |
5.401 |
5.402 |
Fenthion |
7.680 |
7.667 |
7.674 |
Pyrazophos |
9.391 |
9.388 |
9.390 |
αEndosulfan |
16.079 |
16.151 |
16.115 |
Phenanthrene |
9.996 |
10.000 |
9.998 |
Diclofop-methyl |
15.719 |
15.712 |
15.716 |
DDT |
53.842 |
53.931 |
53.887 |
The capacity factor (k) and log10 Koc values for the reference standards
Standard |
Capacity Factor (k) |
Log10 k |
Log10 Koc |
Acetanilide |
8.780 x 10-2 |
-1.057 |
1.25 |
Phenol |
7.486 x 10-2 |
-1.126 |
1.32 |
Atrazine |
0.244 |
-0.613 |
1.81 |
Isoproturon |
0.307 |
-0.513 |
1.86 |
Naphthalene |
0.644 |
-0.191 |
2.75 |
Fenthion |
1.335 |
0.126 |
3.31 |
Pyrazophos |
1.857 |
0.269 |
3.65 |
αEndosulfan |
3.904 |
0.592 |
4.09 |
Phenanthrene |
2.043 |
0.310 |
4.09 |
Diclofop-methyl |
3.783 |
0.578 |
4.20 |
DDT |
15.399 |
1.187 |
5.63 |
The retention times, capacity factors and log10 Koc values determined for the sample
Injection |
Retention time (mins) |
Capacity factor (k) |
Log10 k |
Log10 Koc |
1 |
8.965 |
1.728 |
0.238 |
3.63 |
2 |
8.945 |
1.722 |
0.236 |
3.63 |
Overall log10 Koc: 3.63
Adsorption coeifficent: 4.24 x 103
Description of key information
Adsorption coefficient determined as 4.24 x 103, log10 Koc 3.63
Key value for chemical safety assessment
- Koc at 20 °C:
- 4 240
Additional information
Adsorption coefficient determined as 4.24 x 103, log10 Koc 3.63, using the OECD draft document (December 1998): Estimation of the Adsorption Coefficient (K,) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC).
[LogKoc: 3.63]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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