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Diss Factsheets
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EC number: 273-381-6 | CAS number: 68958-92-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- expert statement
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- other: expert statement based on available study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
- Objective of study:
- other: TK assessment based on available data
Test material
- Reference substance name:
- Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,S']dioxodi-μ-thioxodimolybdenum
- EC Number:
- 273-381-6
- EC Name:
- Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,S']dioxodi-μ-thioxodimolybdenum
- Cas Number:
- 68958-92-9
- Molecular formula:
- C32H68Mo2O6P2S6
- IUPAC Name:
- Bis[O,O-bis(2-ethylhexyl) dithiophosphorato-S,S']dioxodi-μ-thioxodimolybdenum
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (S-930), but data currently available on physical-chemical properties and from in vivo and in vitro toxicology studies were evaluated.
After oral administration, in general, a compound needs to be dissolved before it can be taken up from the gastrointestinal tract. As the water solubility of S-930 is very limited with≤0.25μg/L at 20°C, only traces of the substance (if any) will dissolve into the gastrointestinal fluids. In addition potential uptake via passive diffusion will be hampered by its large molecular weight (995). S-930 is lipophilic, as reflected in its partition coefficient (log Pow > 8.7). This implies that the substance may be taken up by micellar solubilisation. The substance has no ionisable groups, which could potentially hamper uptake.
For risk assessment purposes oral absorption of S-930 is set at 50%, based on its limited water solubility and its high molecular weight and taking into account its lipophilicity, which is expected to result in micellar solubilisation, after which some uptake is expected. The oral toxicity data do not provide reason to deviate from the proposed oral absorption factor.
Once absorbed, distribution of the substance throughout the body is expected to be limited based on its limited water solubility and high molecular weight. Absorbed S-930 is expected to be excreted via urine and via bile. Based on its high partition coefficient (log Pow > 8.7), it is likely that S-930 will accumulate in adipose tissue.
S-930 has a very low vapour pressure (below 4.0*10-3 Pa at 25°C), which indicates that exposure via air will be very limited. However, since S-930 is a liquid, exposure can be expected after formation of aerosols. If aerosols reach the tracheobronchial region, S-930 is not expected to dissolve in the mucus lining the respiratory tract as the water solubility is very low. The substance can be coughed or sneezed out of the body. As lipophilic substances have the potential to be absorbed directly across the respiratory tract epithelium, some uptake can be expected, although this is expected limited related to its high molecular weight. Taking all data together, it is concluded that for risk assessment purposes as worst case the inhalation absorption of S-930 should be set at 10%.
As S-930 is a liquid, uptake through the skin can take place. As the water solubility of S-930 is limited, partition from the stratum corneum into the epidermis is expected to be low. On the other hand, its ability to dissolve in lipids will favour crossing of epidermal barriers. Any movement through a skin barrier will be hampered by its molecular size. According to the criteria given in the REACH Guidance, 10% dermal absorption will be considered in case MW >500 and log Pow <-1 or >4, otherwise 100% dermal absorption should be used. As the physical/chemical properties of S-930 do meet the criteria for limited dermal absorption (MW 995; log Pow > 8.7), for risk assessment purposes dermal absorption is set at 10%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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