Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 February 2018 to 07 March 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Guideline study as required by REACH regulation 1907/2006

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

23 March 2006

Deviations:

not specified

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

not specified

GLP compliance:

no

Type of method:

dynamic method

Remarks:

Grain-Watson estimation

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: NA2253
- CAS number: 14306-25-3
- EC number: 238-242-6
- Appearance: White solid at ambient temperature
- Expiration date of the lot/batch: June 2019

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

<= 0.001 atm

Remarks on result:

other: the calculation is based on the lowest possible boiling temperature according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

Key result

Test no.:

#2

Temp.:

50 °C

Vapour pressure:

<= 0.013 atm

Remarks on result:

other: the calculation is based on the lowest possible boiling temperature) according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

Study Results

The test item has a vapour pressure of ≤1.1*10^-3atm (≤1.1*10²Pa; ≤1.1*10⁰mbar) at 20 °C andof ≤1.3*10^-2 atm (≤1.3*10³Pa; ≤1.3*10¹mbar) at 50 °C (the calculation is based on the lowest possible boiling temperature) according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

 The experimentally determined vapour pressure of the test item at 20 °C (see DSC-diagrams 1, 3 and 4, “Experimental determined vapour pressure curve”) is not in the recommended range of 1 to 1000 mbar for DSC-measurements.

Therefore an estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23^rdMarch 2006, Vapour Pressure” ANNEX Estimation Methodnewest version(Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used. This method is applied for vapour pressures between 10³to 10^-7mbar. This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

 Please note:

Substances with a higher vapour pressure need to be assessed more critically, e.g. concerning the release of toxic substances, than those with a lower vapour pressure.

An estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23^rdMarch 2006, Vapour Pressure” ANNEX Estimation Method newest version(Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used. This method is applied for vapour pressures between 10³to 10^-7mbar.

This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

 

Conclusions:

The test item dermofeel® PA-3 (dried) has a vapour pressure of ≤ 0.0011 atm (≤ 110 Pa; ≤ 1.1 mbar) at 20 °C and of ≤ 0.013 atm (≤ 1300 Pa; ≤ 13 mbar) at 50 °C (the calculation is based on the lowest possible boiling temperature) according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

Executive summary:

The test item has a vapour pressure of ≤ 1.1*10 ^-3 atm (≤ 1.1*10² Pa; ≤ 1.1*10⁰ mbar) at 20 °C and of ≤ 1.3*10 ^-2 atm (≤ 1.3*10³ Pa; ≤1.3*10¹ mbar) at 50 °C (the calculation is based on the lowest possible boiling temperature) according to the definition in the OECD Guideline 104 (Grain-Watson estimation).

The experimentally determined vapour pressure of the test item at 20 °C is not in the recommended range of 1 to 1000 mbar for DSC-measurements. Therefore an estimation procedure in accordance with the test method OECD Guideline 104 “OECD Guideline For The Testing Of Chemicals, adopted by the Council on 23^rdMarch 2006, Vapour Pressure” ANNEX Estimation Method newest version (Robert S. Boethling, Donald Mackay, Handbook of Property Estimation Methods for Chemicals, Lewis Publishers, year of publication 2000, Cap. 3 - Vapour Pressure, Grain-Watson Method, p. 53 – 65) was used. This method is applied for vapour pressures between 10³to 10^-7mbar. This deviates from the older version published in OECD Guideline 104. It was used due to the differentiation between solids and liquids, which results in a more precise estimate.

 

Key value for chemical safety assessment

Vapour pressure:

1 300 Pa

at the temperature of:

50 °C